The invention discloses an anti-radiation moisture-retention sun screen and a preparation method thereof. The sun screen comprises the following materials: polydimethylsiloxane, mineral oil, ethyl palmitate, isopropyl isostearate, titanium dioxide, polyglycerol-2-distearate, a polydimethylsiloxane/vinyl polydimethylsiloxane rosslinked polymer, a rhodiola root extract, a honey extract, a cetyl polydimethylsiloxane, a cetyl PEG/PPG-10/1 polydimethylsiloxane, petrolatum, isoamyl nonanoate, mica/dimethicone, polyglycerol-10, bio-sugar gum 1, trehalose, hyaluronic acid, organic cosmetic pigments, inorganic cosmetic pigments, a preservative, essence, and water. The sun screen is safe, non-irritating and stable in quality, and contains the natural substances such as the honey extract and the rhodiola root extract, and the sun screen is clear and skin-friendly, and no sticky after use, has the characteristics of good moisturizing, skin moisturizing, good isolation and concealing effect.