According to the technical scheme of the interference alignment iterative calculation method and device, the storage medium and the computer equipment provided by the embodiment of the invention, according to the obtained initial interference subspace matrix, the obtained local channel gain matrix and the obtained transmission precoding matrix, through the pre-established optimization algorithm model, an updated interference subspace matrix is generated, and the updated interference subspace matrix is input into the base station, so that the base station generates an updated transmission precoding matrix; 1 is added to the set number n of iterations; according to the received updated interference subspace matrix output by the transceiver, through a pre-established optimization problem model, outputting an updated transmission precoding matrix, adding 1 to a set number of iterations, and if the number of iterations is equal to a preset number of times, the output interference subspace matrix and the transmitting precoding matrix are used as optimal solutions, so that the anti-interference performance of the transceiver is improved, and the robustness of interference alignment iterative calculation is improved.