The invention discloses a soda saline-alkali land comprehensive treatment agent and a use method thereof, and belongs to the technical field of control agents for improving moderate and severe soda salinization. The comprehensive treatment agent consists of a modifier and an organic fertilizer, wherein, components of the modifier comprise humic acid, zeolite, a acid conditioner, fly ash and furfural residue; and the components of the organic fertilizer comprise fermented chicken manure, crushed straw and wood vinegar liquid. The comprehensive treatment agent is applied at 13-17t per 1 hectare of saline-alkali land before harrowing and transplanting. The action mechanism of the soda saline alkali land comprehensive treatment agent integrate physical and chemical functions of chemical salifying, complexing, neutralizing, ion exchange, adsorption, desorption, passivation, fixing, preventing salt accumulation, emulsion breaking and like; which increase CEC by times, desorbs and leaches base and basic group in soil, significantly decrease the pH value, greatly reduce soluble Na ions; and a formed anti-salt accumulation plow pan structure really takes effect of 'salt isolation' and 'alkali decrease', thus realizing rice harvest in the same year of construction and cultivation.