The invention discloses a device for interactive reaction between heavy metals and particulate matter and belongs to the field of interactive reaction devices. The device comprises a flue gas mixing system, a temperature control hearth and a tail gas processing system, wherein a temperature control device is arranged in the temperature control hearth, an ejector, an atomizer and a sampling hole are respectively arranged outside of the temperature control hearth, the front end of the ejector is connected with one end of the flue gas mixing system and one end of the atomizer respectively, the other end of the atomizer is connected with a peristaltic pump, and the tail end of the temperature control hearth is connected with the tail gas processing system. The device can be used for researching a reaction mechanism of specific ingredients of particulate matter and heavy metals under different conditions in different concentrations of heavy metal atmospheres, and the peristaltic pump combines with an atomizer and double-by-path venturi ejector combined device, so that the particulate matter and the heavy metal atmospheres re evenly mixed, and control is convenient. In addition, feeding is performed from the cylindrical tangent plane of the hearth, so that mixing is violent, and the staying time of fine particulate matter and heavy metal flue gas in the hearth is also prolonged.