The invention provides a fabric, in particular to a mulberry silk and cuprammonium rayon yarn interwoven fabric. The fabric is interwoven by the mulberry silk and the cuprammonium rayon yarn, wherein warp is made of the mulberry silk, while weft is made of the cuprammonium rayon. The invention also provides a method for weaving the fabric, which is a method of interweaving the mulberry silk warp and the cuprammonium rayon yarn weft into the fabric, wherein the cuprammonium rayon yarn as the weft is subjected to predrying treatment before use; process steps of the warp and the weft are as follows: the warp adopts reeled silk to be subjected to rolling, primary twisting, doubling, second twisting, skeining, degumming, dyeing, rolling, warping and weaving; and the weft adopts cone winded yarns to be subjected to roll separating, twisting, skeining, dyeing, rolling, quilling, predrying and weaving. The method provides the product interwoven by the mulberry silk and the cuprammonium rayon yarn, and adds new content for colorful silk variety.