The invention relates to an auxiliary mixed medicament of fish medicine. The medicament is prepared from, 2-4 parts of aldehyde bactericide, 2-6 parts of triazine bactericide, 1-3 parts of pyridine bactericide, 2-5 parts of dispersing agent, 1-2 parts of surface active agent, 2-3 parts of disintegrating agent, 1-5 parts of anti-freezing agent, 2-7 parts of thickening agent, 11-13 parts of chemicaloxygen producer, 1-2 parts of biological bacterial agent, 0.1-0.2 part of sodium citrate, 0.6-1 part of binding agent and 300-360 parts of water. The auxiliary mixed medicament of the fish medicine has the advantages that when the air temperature rises, the temperature of surface water gradually rises, and the density gradually declines; the air temperature is lower than the water temperature atnight, when the air temperature gradually declines, the temperature of the surface water also gradually declines, the density gradually rises, so that the density of the surface water is larger than that of bottom water, accordingly convection of upper and lower water is caused, and a sterilization medicament flows to the underwater position along with water; a large quantity of pathogenic bacteria in bottom sludge is effectively prevented from being carried to the whole water, the opportunity that cultured fishes are in contact with the pathogenic bacteria is reduced, fish diseases are reduced, and meanwhile the content of bottom oxygen is increased by putting oxygen producer at the same time.