The invention provides a multi-detector optical system linkage focusing mechanism and a focusing method thereof. The multi-detector optical system linkage focusing mechanism comprises a medium focal length optical sub-system, a long focal length optical sub-system, a short focal length optical sub-system, detectors, an object plane distance calculating unit, a reactive circuit, position control units, a position measuring unit, a focusing unit and a detector mobile module, wherein there are three detectors which are respectively connected with the medium focal length optical sub-system, the long focal length optical sub-system and the short focal length optical sub-system; the object plane distance calculating unit is connected with the reactive circuit; and the object plane distance calculating unit is connected with the medium focal length optical sub-system, the long focal length optical sub-system and the short focal length optical sub-system. According to the invention, the multi-detector optical system linkage focusing mechanism has the advantages of simple control, high focusing precision, lightness, convenience, substantially reduced waste of labor and material resources, and the like.