The invention discloses a pest control method for efficient cultivation of polygonum multiflorum, which comprises agricultural control, physical control, biological control and chemical control. The agricultural control comprises the following steps: in summer and autumn, after harvesting the last batch of crops, deep ploughing and drying upturned soil in time, exposing and drying the soil, wherein the thickness of deep ploughing is 25-30 cm, and the exposing and drying time is 30 days. By the method that in summer and winter, after harvesting the last batch of crops, the upturned soil is deeply ploughed and dried in time, and the soil is exposed and dried, wherein the thickness of deep ploughing is 25-30 cm, and the exposing and drying time is 30 days, germs invading polygonum multiflorum plants can be conveniently controlled; and thus the control efficiency is improved. The ploughing depth can reduce requirements to the ploughing tools and machines. In addition, the exposing and drying time is limited to be 30 days, which not only cannot enable the nutritional components in the soil to be lost, but also can improve the physical behaviors of the soil, reduce influence of the pest and disease damage to polygonum multiflorum, ensure the emergence rate of polygonum multiflorum, and improve the output of polygonum multiflorum.