The present invention provides a pipeline reliability testing device which comprises a drying module, a temperature control module, a testing module and a pulse pressure generator installed in order. The gas outlet end of the drying module is divided into two paths which are respectively connected with the heating gas path and the cooling gas path of the temperature control module, the testing module is at least one testing gas paths which are installed in parallel, the hand of the robot of a vibration device stretches into a test box, a testboard is installed at the end portion of the handle, and the handle drives the testboard and pipeline samples to realize three-axial vibration. The vibration device is simple in structure so as to simulate different temperatures, pulse pressures and vibration conditions of an engine in a working process and test the reliability of a turbocharging tube with no need for configuration of a special engine, the test structure is simple, and the cost is saved. The vibration detection device is connected with the testboard, the amplitudes and frequencies of the three-axial directions of the vibration block are the completely same as these of the handle, and displacement sensors of three directions are employed to accurately detect the amplitudes and the frequencies of three-axial direction vibration so as to ensure that the real vibration effect accords with the test requirements.