The invention discloses a manufacturing method of a multilayer copper-based sandwich bent plate. The method comprises the steps of sandwich copper base and FR4 board cutting, FR4 board inner layer circuit manufacturing, high-temperature glue pasting, press fit, drilling, copper deposition plate electroplating, outer layer circuit manufacturing, pattern electroplating, outer layer etching, outer layer A01 detection, soldermask process, forming, high-temperature glue tearing, FQC1, tin deposition, copper base bending, FQC2 and final packaging process. According to the manufacturing method, the cost of an FR4 plate is reduced; the production efficiency and yield of the plate are improved; production cost is reduced; and the manufacturing process of the sandwich copper-based bent plate is simplified.