The invention discloses a manufacturing process of a high-precision extrusion die for a DeNOx catalyst. The manufacturing process comprises the following steps: discharging, thermal refining, grinding, rough machining, grinding, boring holes, semi-fine grinding, thermal treatment, groove linear cutting, benching, fine grinding and protective treatment. In the process, by means of the methods such as reasonable control of machining amount, reasonable selection of equipment parameters and the like in the steps, the surface roughness, the dimensional precision and the form and position accuracy of holes (grooves) of machined parts of the extrusion die with multiple deep holes (grooves) for the catalyst are effectively ensured, wherein, the machining precision reaches 0.01mm, and the surface roughness reaches over Ra0.8; the machining process is stable and reliable; the qualification rate of the die product reaches over 99%; and the difficulty in manufacturing the complicated die with the multiple deep holes (grooves) is overcome. Compared with the prior art, the manufacturing process disclosed by the invention has the advantages of effectively avoiding scrap caused by size and location out-of-tolerance, greatly lowering production cost, improving machining efficiency and shortening production cycle.