The invention relates to the technical field of precision machine manufacturing, in particular to additive and subtractive composite manufacturing process equipment which comprises a protective cover,a subtractive device and a support. The subtractive device and the support are arranged in the protective cover, and the subtractive device is provided with an electric spindle with X, Y and Z degrees of freedom and a laser galvanometer with X degrees of freedom. A powder spreading device, a powder supply box and a forming box are arranged on the support, the powder spreading device is provided with a powder spreading panel and a movable scraper, a powder supply port and a forming port are formed in the powder spreading panel, the powder supply box is arranged on the lower side of the powdersupply port, a liftable powder supply piston is arranged in the powder supply box, and the forming box is arranged on the lower side of the forming port. A liftable forming piston is arranged in the forming box, a powder supply moving mechanism is arranged in the support, and the powder supply box is driven by the powder supply moving mechanism to move between the powder supply port and a powder supplementing port. The equipment is reasonable in space layout, good in sealing performance, accurate in powder supply and capable of achieving online detection, the machining quality and precision are guaranteed, and the machining efficiency is improved.