The invention discloses a high-density polyethylene alloy pipe and a manufacturing method thereof. High-density polyethylene 100 (HDPE 100) is used as base resin, high-density polyethylene-g-maleic anhydride (HDPE-g-MAH) is used as a compatilizer, calcium carbonate (CaCO3) and low-density polyethylene (LDPE) are added into the base resin and the compatilizer, and the mixture is blended with modifier polyamide 6 (PA6) to form a modified polyethylene (PE) alloy product. The method comprises the main operation steps of: (I) preparing HDPE modified granules; and (II) adding the modifier PA6, performing high-speed mixing to form a modified PE mixture, and extruding the modified PE mixture into the product in an extruder. According to the technical scheme, the high-density polyethylene alloy pipe overcomes the defects the defects that the conventional polyethylene resin has low tensile strength, poor rigidity and poor abrasion resistance, chemical resistance, environmental stress cracking resistance and heat resistance, has insufficient blocking property on hydrocarbon solvents and fuel oil, is easily damaged by ultraviolet under the irradiation of sunlight, seriously affects the service life of the product and the like; and the high-density polyethylene alloy pipe is suitable to be used as various heat resistant, abrasion resistant and temperature resistant pipes, and is particularly suitable for pipeline transportation of special industries of drainage, fuel gas and fuel oil delivery, chemistry and chemical industry and the like.