The invention belongs to the technical field of manufacturing of 
radiation resources and particularly relates to a device for manufacturing a high-resolution alpha 
radiation source with a 
magnetohydrodynamics electro-deposition method. The structure of the device comprises a two-dimensional locating support and a permanent 
magnet regulating and controlling table top arranged on the two-dimensional locating support, a deposition groove containing deposition solution is formed in the middle of the permanent 
magnet regulating and controlling table top. The two sides of the deposition groove are provided with a 
magnet fixing plate and a displacement transmission device, wherein the magnet fixing plate is used for fixing a permanent magnet, and the displacement transmission device is used for adjusting the permanent magnet. An 
electrode is arranged on the upper portion of the two-dimensional locating support, and an 
anode wire is installed at the lower end of the 
electrode. The 
anode wire extends into the deposition solution from the top of the deposition groove. A 
cathode deposition source sheet and a 
cathode leading-out 
gasket which are in tight contact with each other are arranged at the bottom of the deposition groove, the bottom of the 
cathode leading-out 
gasket is connected with a cathode leading-out wire, and the cathode leading-out wire is connected with the negative 
electrode of a power source. When the device is used for manufacturing the alpha 
radiation source, good deposition efficiency and good energy resolution are obtained, and the 
operation safety can be greatly improved.