The invention relates to a
noble metal and
refractory multi-principal component substrate combined high-entropy
alloy catalyst, a preparation method and acidic OER application. The catalyst is a high-entropy
alloy formed by a
refractory metal component A and a
noble metal active component B, the component expression is AxBy, A is selected from multiple of Ta, Nb, Hf, Zr, Ti, W and Mo, and B is selected from at least one of Ir, Os and Ru. The structure of a precursor is regulated and controlled through
physical metallurgy alloying, a unique structure that a dendritic
refractory metal component supports a granular
active component is obtained through a dealloying technology, and the catalyst can be directly used for an acidic OER catalyst, has activity and stability under the working condition of
high current density, has the characteristics of low
precious metal consumption and capability of being prepared in a large scale, and is suitable for industrial production. The method has the practical application potential as a PEM
electrolytic cell catalyst.