176 results about "Seed grape" patented technology

The invention discloses a natural vegetable oil composition as well as a preparation method and application thereof. The natural vegetable oil composition comprises sunflower seed oil, simmondsia chinensis seed oil, grape seed oil and camellia seed oil. The feeding mass ratio of the sunflower seed oil to the simmondsia chinensis seed oil to the grape seed oil to the camellia seed oil is 1: (0.5-1.5): (0.5-1.5): (0.5-1.5); the components are uniformly mixed during preparation, practice shows that the combination of the four natural plant-derived oils has an excellent moisturizing effect and a skin repairing effect and has a remarkably better and more balanced effect compared with a single or partial combination of the four natural plant-derived oils, and particularly, the remarkable moisturizing and skin repairing effects can be obtained only by a small addition amount; the composition is beneficial to addition and use in cosmetics, does not need to adopt excessive emulsifiers for additional emulsification and dispersion, is beneficial to reduction of irritation brought by the emulsifiers, and is good in use experience.

The invention relates to the technical field of collagen peptide extraction, and particularly discloses aquatic collagen tripeptide and a processing technology thereof, and the processing technology comprises the following steps: step S1, fish skin pretreatment; step S2, performing enzymolysis; step S3, fermentation; step S4, separation and purification; starting from three aspects, firstly, a modified degreasing agent is added in the degreasing treatment process, the modified degreasing agent takes 1-ethyl-3-methylimidazole acetate, zinc phytate and calcium citrate as main components according to a specific mass ratio, and secondly, gel emulsion is added in the enzymolysis process, so that the modified degreasing agent is prepared. The gel emulsion has an oil gel structure, grape seed oil and sodium lignin sulfonate, and 3, a composite strain is added in the fermentation process, the composite strain is prepared by mixing bacillus natto and lactobacillus plantarum according to a specific proportion, and the purity and the extraction rate of the aquatic collagen tripeptide are improved through the synergistic effect of all the procedures.

The invention belongs to the technical field of hair dyes, and particularly relates to an ammonia-free low-sensitivity essential oil composition for hair dyeing as well as a preparation method and application of the ammonia-free low-sensitivity essential oil composition. The ammonia-free low-sensitivity essential oil composition for hair dyeing is prepared from the following components: coconut oil, camellia seed oil, grape seed oil, macadamia seed oil, simmondsia chinensis seed oil and squalane. The ammonia-free low-sensitivity essential oil composition provided by the invention can simultaneously meet the effects of low irritation, high coloring effect and high dyeing durability.

The invention belongs to the technical field of cosmetics, and particularly relates to a water-in-oil-in-water three-phase coated microbead as well as a preparation method and application thereof. The water-in-oil-in-water three-phase coated microbead is of a spherical structure and sequentially comprises an outer water phase, an inner oil phase and an inner water phase from outside to inside, the outer water phase comprises sodium alginate, agarose, cyclodextrin, glycerin and other components, the inner oil phase comprises caprylic / capric triglyceride, grape seed oil, olive squalane, tocopherol and other components, and the inner water phase comprises sodium alginate, agarose, cyclodextrin, glycerin and other components. And the inner water phase comprises ampelopsis grossedentata extract, astragalus membranacus root extract and other components. According to the invention, an easily oxidized and unstable active matter is fully and firmly protected by adopting a droplet microfluidic coating technology, so that the active matter is free from external stimulation, active ingredients with different effects play multiple roles, and the composition has good anti-inflammatory, soothing and oil-controlling effects and can be applied to the field of cosmetics.

The invention relates to the technical field of plant essential oil, in particular to natural acne removing and repairing plant essential oil and a preparation method and application thereof. The natural acne removing and repairing plant essential oil is prepared from, by weight, 40-60 parts of mixed oil, 40-60 parts of lavender essential oil, 20-30 parts of tea tree essential oil, 20-30 parts of chamomile essential oil, 20-30 parts of additive liquid, 10-20 parts of grape seed oil, 6-10 parts of pomelo essential oil, 2-4 parts of solubilizer and 0.8-0.12 part of dispersing agent. According to the preparation method, mesophyll tissues in the tea leaves can be separated through enzymolysis, rough vein components in the tea leaves are removed, so that the extract is finer, the smearing comfort of essential oil is improved, the tannic acid component rich in the tea leaves is utilized, and tannic acid can inhibit growth and reproduction of bacteria in acne, so that the skin is kept in a clean state; the acne symptom is improved, and meanwhile, the recurrence rate of the acne is effectively reduced.

The present invention discloses a composition for improving chloasma, and its preparation method and application, for solving the problem that when oral tranexamic acid is stopped for a period of time during the treatment of chloasma, the problem of recurrence will occur after a short time. A composition for improving chloasma, in parts by weight, comprising the following raw material components: 1-10 parts of tomato seed oil, 10-15 parts of grape seed extract, 1-10 parts of Guanshan cherry, 1-15 parts of beeswax, 20-60 parts of vegetable oil, 20-60 parts of gel peel; wherein, the gel peel is composed of gelatin, glycerin and water. The composition provided by the application has a synergistic effect on inhibiting the production of melanin among the components. A preparation method for improving chloasma composition, the preparation method is simple, the steps are controllable, and the quality and stability of the composition for improving chloasma are improved. An application is also provided, the composition for improving chloasma has excellent inhibition of melanin production, and is rich in a variety of antioxidant active substances, and has a very excellent effect on freckle removal and whitening.

The invention discloses a grape seed protein peptide with DPP-IV inhibitory activity and a preparation method thereof, and belongs to the field of comprehensive utilization of wine fermentation byproducts. The grape seed protein peptide disclosed by the invention is prepared from a zymolyte obtained by carrying out alkaline protease enzymolysis on grape seed protein prepared from grape seeds by an ultrasonic-assisted alkaline method. The grape seed protein peptide disclosed by the invention has a good DPP-IV inhibition effect, is a DPP-IV inhibitor from a natural plant source, and can be applied to functional foods and nutritional health-care products.

The invention provides an anti-aging composition containing sea cucumber peptide and a preparation method of the anti-aging composition, and belongs to the technical field of cosmetics. Mixing the sea cucumber peptide compound, the fermented smallanthus sonchifolius extract, the grape seed extract and the clam peptide at 23-25 DEG C for 10-15 minutes to obtain a mixture; the preparation method comprises the following steps: dispersing xanthan gum and sodium carboxymethyl cellulose in purified water at 85-90 DEG C, and stirring and mixing for 20-30 minutes to obtain a mixed system A; mixing the mixed system A, sodium hyaluronate, butanediol, hydroxyethyl urea, stearyl alcohol polyether-21 and glycosylglycerol at 50-55 DEG C for 10-15 minutes to obtain a mixed system B; and mixing the mixed system B and the mixture at 40-45 DEG C for 20-30 minutes to obtain the anti-aging composition. The sea cucumber peptide and the clam peptide jointly stimulate collagen synthesis through the synergistic effect, and good anti-aging and moisturizing effects are achieved through the synergistic effect of multiple components.

The invention provides injectable adhesive hydrogel for treating chronic periodontitis, and belongs to the technical field of medical materials. The preparation method of the injectable adhesive hydrogel comprises the following steps: dropwise adding a Zn (NO3) 2.6 H2O aqueous solution into a grape seed extract aqueous solution, carrying out flocculent precipitation, and collecting the precipitate to obtain grape seed extract-zinc coordination nanoparticles; the preparation method comprises the following steps: dissolving methacrylic acid modified gelatin, oxidized hyaluronic acid and a photoinitiator in water to obtain a hydrogel precursor solution 1; adding grape seed extract-zinc coordination nanoparticles and melittin into the hydrogel precursor solution 1 to obtain a hydrogel precursor solution 2; and irradiating the hydrogel precursor solution 2 with blue light to obtain the injectable adhesive hydrogel. The hydrogel provided by the invention has good mechanical and rheological properties, can be effectively adhered to various fresh and moist tissues and materials, and has good cell compatibility. The excellent effects of resisting bacteria, diminishing inflammation and regulating and controlling the immune microenvironment are achieved.

The invention provides coconut oil essence hand cream and a preparation method thereof. The hand cream is prepared from the following raw materials in parts by weight: 18 to 24 parts of coconut oil essence, 12 to 15 parts of compound tremella extract, 3 to 6 parts of fig fruit extract, 7 to 10 parts of grape seed oil, 6 to 9 parts of olive fruit oil, 4 to 7 parts of squalane, 5 to 8 parts of fucoidin, 3 to 6 parts of galactooligosaccharide, 2 to 4 parts of dipotassium glycyrrhizinate, 10 to 14 parts of propylene glycol, 12 to 15 parts of glycerol, 0.01 to 0.05 part of preservative, 10 to 14 parts of sucrose fatty acid ester, 13 to 17 parts of sorbitan olivate, 0.2 to 0.6 part of essence and 140 to 180 parts of water. Through the mutual synergistic effect of the raw materials such as the coconut oil essence, the composite tremella extract, the fig extract, the grape seed oil, the olive fruit oil, the squalane, the fucoidin and the galactooligosaccharide, moisture of hand skin can be effectively locked, a protective layer is formed on the surface layer of the skin, loss of moisture of the hand skin is reduced, and the hand cream has a good hand moisturizing effect. Therefore, the hand skin is kept in a moisturized state, and the problems of skin dryness, desquamation, cracking and the like are effectively reduced.

The invention discloses essence oil, which is prepared from the following ingredients in parts by weight: 0.1 to 0.5 part of ethylhexyl palmitate, 0.5 to 0.8 part of tocopheryl acetate, 0.1 to 0.2 part of vanillyl butyl ether, 10 to 15 parts of herba speranskiae tuberculatae extracts, 5 to 10 parts of flos carthami extracts, 1 to 5 parts of sunflower seed oil, 5 to 10 parts of grape seed oil, 1 to 5 parts of olive fruit oil, 2 to 6 parts of angelica rotundifolia root oil and 2 to 6 parts of camphor tree bark oil. The oil is easy to push away, non-sticky, refreshing, easy to absorb and capable of forming a lasting protective oil film; the components are simple and clean, effective components can permeate into the scalp and reach the hair roots to nourish hair follicles, deeply repair hair quality and integrally relieve and relax the scalp, and the smell is fresh.

The invention discloses bath oil with stability and foamability and a preparation method thereof, and relates to the technical field of daily chemical products. The vegetable oil consists of peony seed oil, grape seed oil and sunflower seed oil in a mass ratio of 1: 2: 2. The bath oil is prepared from the following raw material components in parts by weight: 45 to 50 parts of vegetable oil, 18 to 22 parts of a surfactant, 16 to 18 parts of fatty alcohol-polyoxyethylene ether, 8 to 12 parts of caprylic / capric triglyceride, 1 to 3 parts of span 80, 0.1 to 0.5 part of an antioxidant, 1 to 3 parts of cocamidomethyl MEA and 0.1 to 2 parts of essence. On the basis of the compound vegetable oil, the optimal adaptive surfactant is screened out, then the compound antioxidant is introduced, and the bath oil which is long-acting, stable, high in foaming quality, clean, mild, nourishing and comfortable is effectively formed.

The invention relates to the technical field of oral preparations, in particular to an improved oral preparation based on traditional Chinese medicine prescription Yufengxiang powder and a preparation method of the oral preparation. The preparation comprises traditional Yufengxiang powder components such as mung beans, radix angelicae, Chinese wolfberry fruits, licorice roots and poria cocos. And modern functional components such as turmeric, grape seeds, low-molecular-weight hyaluronic acid, L-ascorbic acid, zinc gluconate, a pumpkin seed extract, black pepper pigment and a rice essence extract. The preparation method comprises the following steps: respectively extracting the raw materials, drying into powder, mixing all active components according to the formula, controlling the moisture content of the powder, and filling into an enteric capsule shell. Through dosage form improvement and formula optimization, the bioavailability of active ingredients is remarkably improved, multiple synergistic effects of whitening, oxidation resistance, moisturizing, nerve soothing, alopecia improvement and the like are achieved, and the technical problems that traditional Yufeng western style powder is low in external use absorption rate and single in function are solved.

This invention discloses a grape seed protein peptide with ACE inhibitory activity and its preparation method, belonging to the field of comprehensive utilization of wine fermentation by-products. This invention provides a grape seed protein peptide with ACE inhibitory activity, wherein the grape seed protein peptide is FFYPL, SGMFPFP, or WFFPGPR. The grape seed protein peptide of this invention can be used in pharmaceuticals; it has broad application prospects in the pharmaceutical field as a preventive or adjunctive treatment for patients with hypertension, or those with obesity, cardiovascular and cerebrovascular diseases, and other chronic metabolic disorders.

The invention discloses a plant cell extract-containing traditional Chinese medicine aromatic penetration enhancer and a preparation method thereof, and the penetration enhancer comprises the following components in parts by mass: 8-15 parts of storax nano-vesicles, 3-8 parts of agilawood nano-vesicles, 1-5 parts of refined turpentine, 0.5-3 parts of panax notoginseng saponins, 0.5-3 parts of rhododendron dauricum oil and 20-35 parts of grape seed oil, the storax nano-vesicles and the agilawood nano-vesicles are exosome-like nano-vesicles extracted from plant secretion, and the particle size of the vesicles is 50-200 nm. Skin interstices are opened, skin meridians and blood are dredged, and accordingly relieving, inflammation resisting, redness improving and skin barrier repairing are achieved.

The invention relates to a fresh flower preservation method which sequentially comprises the following steps: manually poking grape seeds, cleaning and drying, grinding powder to obtain grape seed powder, adding ethanol in a ratio of 1: 10, adopting a microwave soaking method to obtain a preservation solution, diluting by 50 times, and uniformly spraying on leaves by adopting a spraying method. According to the fresh flower preservation method provided by the invention, the storage time of the petals of the fresh flowers can be prolonged, the colors of the petals cannot be obviously changed after the petals are placed for a long time, meanwhile, the period of water loss and withering is also greatly prolonged, and the sales range of the fresh flowers is expanded.

The present invention specifically relates to an anti-cracking and repairing composition containing artemisia annua and camellia seed oil, and its preparation and application, belonging to the technical field of cosmetics. The composition of the present invention is prepared by using allantoin, phenoxyethanol, ethylhexylglycerin, artemisia annua extract, urea, tocopherol, camellia seed oil, PEG / PPG-14 / 7 dimethyl ether, cholesteryl polyether-10, portulaca oleracea extract, taraxacum extract, grape seed oil, squalane, caprylic / capric triglyceride, bis(lauroyl glutamine) lysine sodium, glycerin, butanediol, carrageenan, sodium carboxymethyl cellulose and water. The cooperation among the raw materials enables the composition to have excellent anti-chapping, skin repairing and nursing, and anti-inflammatory and soothing effects, and at the same time has good stability and safety effects.

The invention provides a soft capsule helpful for improving the function of chloasma as well as a preparation method and application thereof, and relates to the technical field of health care products. The soft capsule comprises a mulberry leaf extract, a seville orange flower extract, a grape seed extract, an almond extract, donkey-hide gelatin powder, vitamin C and vitamin E. The soft capsule provided by the invention exerts the overall effect of improving chloasma through a multi-target synergistic mechanism from inside to outside: the mulberry leaf extract and the grape seed extract block melanogenesis from the source and resist ultraviolet damage by inhibiting tyrosinase activity and strongly resisting oxidation; the seville orange flower extract is used for soothing liver and regulating qi, and regulating internal pathogenesis; the almond extract and the donkey-hide gelatin powder have the effects of promoting blood circulation to remove blood stasis and nourishing yin and blood, improve microcirculation and nourish skin; vitamin C and vitamin E form an anti-oxidation cycle, so that melanin intermediates are directly reduced, and cell membranes are protected. All the raw materials supplement each other to jointly achieve the comprehensive effects of fading stains, brightening the skin color and improving the skin quality.

The invention discloses an anti-wrinkle skin care product composition and a facial mask.The anti-wrinkle skin care product composition comprises an active phase and a basic phase, and the active phase comprises I-type collagen peptide, a ginseng extract, a grape seed extract, an aloe extract and a turmeric extract; the base phase comprises a humectant. According to the technical scheme, the problem that skin collagen is difficult to supplement in a transdermal way is solved.

The invention discloses fragrance essential oil capable of improving attention and a preparation method of the fragrance essential oil, and belongs to the technical field of fragrance essential oil. Comprising the following raw materials in percentage by mass: 58.55% of grape seed oil, 10% of French miscellaneous lavender oil, 10% of sweet orange bergamot oil, 10% of rosemary oil, 10% of dementholized peppermint oil, 0.5% of cinnamomum camphora basil oil, 0.5% of French clary sage oil, 0.2% of frankincense oil, 0.1% of Roman chamomile oil, 0.05% of Indian sandalwood oil and 0.1% of sea vetiver root oil. The automobile air freshener is natural essential oil, does not have chemical smell, can improve multi-layer fragrance, improves air in an automobile, and can remove and weaken negative emotion, stabilize emotion, improve attention and thinking clarity, and improve alertness and reaction speed.

The invention relates to a manufacturing method of a low-cost high-antioxidant-activity liquid carbon dot packaging material. The manufacturing method comprises the following steps: firstly, collecting fresh grape skin and grape seeds, cleaning, drying, crushing and sieving to obtain grape skin and seed powder; then mixing the grape skin and seed powder with deionized water, and performing ultrasonic treatment to obtain a carbon dot precursor solution; performing high-temperature and high-pressure hydrothermal treatment on the carbon dot precursor solution to obtain a carbon dot solution; centrifuging the obtained carbon dot solution, and freeze-drying the obtained supernatant to obtain carbon dot powder; and finally, dissolving gelatin and glycerol in distilled water, and dissolving the carbon dot powder in the mixture to obtain the liquid carbon dot. The green, environment-friendly and high-efficiency liquid carbon dots are synthesized from grape production and processing byproducts through a hydrothermal synthesis method, and are applied to coarse cereals such as brown rice, so that the storage period is prolonged, the taste is improved, the application of the liquid carbon dots in food packaging materials is widened, and the method has great feasibility.

The invention relates to the technical field of collagen peptide extraction, and specifically discloses an aquatic collagen tripeptide and a processing technology thereof. The process comprises the following steps: step S1, pretreating fish skin; step S2, enzymatic hydrolysis; step S3, fermentation; and step S4, separation and purification. The invention proceeds from three aspects: first, a modified degreasing agent is added during the degreasing process, wherein the modified degreasing agent comprises 1-ethyl-3-methylimidazole acetate, zinc phytate and calcium citrate in a specific mass ratio as main components; second, a gel emulsion is added during the enzymatic hydrolysis process, wherein the gel emulsion has an oil gel structure, grape seed oil and sodium lignin sulfonate; and third, a composite strain is added during the fermentation process, wherein the composite strain is prepared by mixing Bacillus natto and Lactobacillus plantarum in a specific ratio. Through the synergistic effect of the above steps, the purity and extraction rate of the aquatic collagen tripeptide are improved.

This invention discloses a selenium-enriched dairy product from selenium-enriched dairy cows and its preparation method, comprising the following components and process characteristics: Basic milk matrix: by mass percentage, containing 85-95% raw milk or reconstituted milk, 0.5-2% milk protein concentrate, and 0.1-0.5% fructooligosaccharides; Probiotic-polyphenol complex: composed of *Lactobacillus plantarum* LP-33 (preservation number CGMCC No. 24567) and grape seed polyphenols, wherein the polyphenols are compounded in a 1:1 ratio with zein-chitosan bilayer microencapsulated form in a free state, with a total addition amount of 50-100 mg / L; Dynamic pH control system: during fermentation, the pH value is monitored in real time and a 0.1-0.5 mol / L sodium bicarbonate buffer solution is automatically added to maintain the pH at 5.0-5.5. This invention achieves breakthroughs in viable count and acid resistance; through dynamic pH control and synergistic protection by polyphenols, the viable count of the finished product is ≥1×10⁻⁶. 9 With a CFU / mL concentration, the survival rate of probiotics in simulated gastric juice for 2 hours is >80%, solving the problem of "high output but low intake" of probiotics in traditional fermentation.

The invention discloses a conditioning and soothing formula of herbal plant extract Yuh with essence oil and a production process thereof, and relates to the technical field of cosmetics. The formula consists of base oil such as coconut oil, sweet almond oil and grape seed oil, and natural herbal plant extraction components such as salvia miltiorrhiza oil, myrrh oil and blumea oil in an accurate proportion, and the sum of the mass percentages of all the components is 100%. The production process adopts the processes of normal-temperature stirring and mixing, physical and chemical inspection, packaging and warehousing, and is free of chemical additives in the whole process, natural, safe and stable. Through the synergistic effect of pure natural plant extracts, the traditional Chinese medicine composition has the double effects of nourishing skin and conditioning meridians and collaterals, soft massage can comb qi activity of the whole body and relieve mental pressure, mild and moist touch can relieve nerves and nourish the meridians and collaterals, component permeation can supplement body fluid of meridian circulation parts and repair body surface skin, and the traditional Chinese medicine composition is suitable for daily skin maintenance and physical and mental relaxation.

The invention relates to a lipidosome with an anti-wrinkle effect in cosmetics and anti-wrinkle skin care cream prepared from the lipidosome. The liposome can be prepared by adopting the following method: firstly, extracting and purifying grape seeds to prepare a grape seed extract; then, licorice is extracted and purified, and a licorice extract is prepared; secondly, preparing liposome with an anti-wrinkle effect by taking the prepared grape seed extract and liquorice extract as raw materials; finally, the liposome with the anti-wrinkle effect is applied to the skin care cream. After the skin care cream is used by people for three months, canthus wrinkles are obviously reduced, and the wrinkle area reduction amount, the wrinkle number reduction amount, the wrinkle length reduction amount and the wrinkle depth reduction amount respectively reach more than 429%, 486%, 297% and 608%.

The invention discloses child skin care essential oil and a preparation method thereof. The child skin care essential oil comprises the following single essential oil in percentage by weight: 35-40% of coconut oil, 1-3% of sweet almond oil, 0.1-0.2% of grapefruit essential oil, 0.05-0.15% of curcuma oil, 0.03-0.06% of black pepper essential oil and the balance of grape seed oil. The obtained skin care essential oil is good in safety to children and has a good skin care effect. Essential oil of each single component is extracted according to different methods, beneficial components are reserved, irritant components are reduced, the essential oil composition is safe, and the skin care effect is improved through the synergistic effect of the coconut oil, the sweet almond oil, the grapefruit essential oil, the curcuma oil, the black pepper essential oil and the grape seed oil.

The present invention belongs to the field of biopharmaceuticals and discloses a vegetable oil ceramide obtained by reacting a vegetable oil fatty acid with a sphingosine-based compound. The sphingosine-based compound is selected from sphingosine, phytosphingosine, and dihydrosphingosine. The vegetable oil fatty acid is selected from olive oil fatty acids, tea oil fatty acids, sea buckthorn oil fatty acids, grape seed oil fatty acids, nut oil fatty acids, borage oil fatty acids, rosehip oil fatty acids, soybean oil fatty acids, and rice bran oil fatty acids. The present invention also discloses a method for synthesizing and using vegetable oil ceramide. Vegetable oil ceramide exhibits excellent properties in repairing the skin's natural barrier, anti-inflammation, tissue healing, and anti-aging, and has broad potential for application in fields such as cosmetics, health care products, and biopharmaceuticals.

The invention relates to the technical fields of medicines, daily chemicals and the like, in particular to a baicalin-based ternary eutectic solvent as well as a preparation method and application thereof. The baicalin is used as a bridge between the matrine and the grape seed oil, and the matrine and the grape seed oil are combined to form a uniform and stable ternary eutectic solvent through weak interaction force such as hydrogen bonds. The problem of solubility of the baicalin is remarkably solved, and the solubility of the baicalin in water and grease is greatly improved. In order to improve the bioavailability of baicalin, baicalin with an efficient anti-inflammatory effect and grape seed oil with a strong anti-oxidation effect are co-dissolved. On the basis of retaining the original anti-inflammatory effect and the like of the baicalin, free radicals can be more effectively cleared, and the ultra-strong antioxidant capacity is exerted, so that a foundation is laid for application of the baicalin in the technical fields of medicines, daily chemicals and the like.

The present application belongs to the field of nutritional biotechnology, in particular, the present application relates to an anti-aging composition and its application. Through a large number of research and screening, it is found that the combination of specific grape seed extract, ergothioneine and specific black ginger extract can exert the synergistic effect of the three, fully exert the grape seed extract (antioxidant, free radical scavenging), black ginger (testosterone enhancement, muscle function enhancement), ergothioneine (protection of mitochondria and lysosome), form a multi-pathway mechanism, multi-level improvement of aging, improvement of fertility and muscle capacity.

The invention belongs to the field of extraction, processing and application of natural plant products, and particularly relates to a preparation method of a grape seed extract and application of the grape seed extract in preparation of a composition for preventing hair loss and growing hair. Tests prove that the grape seed extract can remarkably promote proliferation of hair papilla cells, inhibit apoptosis of the hair papilla cells and remarkably promote expression of factors representing that hair papilla enters an active cycle, is beneficial to inducing or maintaining the growth period of hair follicles and achieving self-rebuilding of the hair follicles, has good effects of preventing hair loss and growing hair, and can be used for preventing hair loss. A new way is provided for development and utilization of the grape seed extract.