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The invention specifically relates to a health-care dark plum-mulberry wine and a preparation method thereof, belonging to the field of medicinal wine. The wine comprises the following components by weight: 100 to 150 parts of dark plum pulp, 60 to 100 parts of mulberry, 50 to 80 parts of seabuckthorn, 30 to 50 parts of spine date seed, 10 to 30 parts of dried ginger, 12 to 20 parts of costustoot, 10 to 15 parts of ginseng, 10 to 15 parts of Chinese angelica, 30 to 50 parts of cassia seed and 300 to 500 parts of base liquor. The preparation method comprises the following steps: a, separately purifying the dark plum pulp and the spine date seed so as to obtain extracts; b, separately squeezing juice from the mulberry and the seabuckthorn so as to obtain mulberry juice and seabuckthorn juice; c, ultrasonically extracting the dried ginger, the costustoot, the ginseng and the cassia seed with an ethanol extraction liquid with ethanol content of 70% to 80% so as to obtain respective extracts thereof; and d, adding the obtained extracts and squeezed juices into the base liquor, then carrying out uniform mixing, sealing the obtained mixture for fermentation at 30 to 40 DEG C for 2 to 3 days and then carrying out fermentation at room temperature for 3 to 5 days so as to obtain the health-care dark plum-mulberry wine.