The invention discloses a soilless cultivation method for lettuce. The method comprises the following steps of seed selection, soilless seedling raising, field planting, daily management and the like.According to the method, soilless seedling raising and soilless cultivation are adopted, soil is not needed, the lettuce is prevented from being polluted by the soil, the cultivated lettuce is free of soil, environmentally friendly, healthy, fresh, juicy, good in taste and high in quality, the growth cycle of the lettuce cultivated by means of the method is short, the utilization rate of a nutrient solution is high, the marketing speed is high, and the economic benefits of vegetable farmers are greatly increased.