The invention discloses a power supply network harmonic suppression method and system capable of resisting impulse noise interference. On the basis of an active filter method, the self-sensing actuator principle is used for fusing a sensing part and an execution part together so as to enable the two parts to transmit information mutually, the defect that when errors occur in sensing signals, harmonic waves cannot be eliminated, or even the signals are worse can be overcome, and meanwhile, the harmonic suppression effect can also be improved; during updating of sub-harmonic weights, the RLS algorithm is adopted, therefore, the defect that step size factors are different to determine in the LMS algorithm is overcome, and the convergence rate is increased. Fractional lower order statistics-fractional lower order correlation (FLOC) is used for processing signals, so that the power supply network harmonic suppression method and system have a certain suppression effect on impulse noise interference. During frequency estimation, the PHD algorithm is used, implementation is simple, the calculated amount is low, a formula for calculating an autocorrelation matrix in the algorithm is improved according to an FLOC calculation method, the influence of impulse noise can be suppressed, and therefore frequency estimation is more accurate.