The invention relates to a profile controlling and flooding composition of a high-temperature, high-
salinity and low-permeability oil reservoir and application thereof in
tertiary oil
recovery of the high-temperature, high-
salinity and low-permeability oil reservoir. The profile controlling and flooding composition aims at solving the problems that in the prior art, the
heat resistant and salt resistant performance of an oil-displacing agent are poor and the flushing efficiency is low under the condition of the high-temperature, high-
salinity and low-permeability oil reservoir. According to the technical scheme, the profile controlling and flooding composition of the high-temperature, high-salinity and low-permeability oil reservoir comprises, by weight, 0.01-3.0% of temperature and salt resistant
polyacrylamide microspheres, 0.01-5.0% of anionic-nonionic surface
active agent, and 92.0-99.98% of injected water, the problems are favorably solved, and the profile controlling and flooding composition can be used for on-spot application of oil
recovery enhancement of deep profile controlling, water plugging, reservoir oil displacing and the like used in the
tertiary oil
recovery of the high-temperature, high-salinity and low-permeability oil reservoir.