The invention discloses an anti-alcoholic dew and a preparation method thereof. The anti-alcoholic dew is characterized by being prepared from the following raw materials in parts by weight: 30-40 parts of corn peptide, 10-20 parts of vinegar, 20-30 parts of honey, 10-20 parts of fructus lycii, 20-30 parts of mulberries, 10-30 parts of rhizoma polygonati, 30-40 parts of radix astragali, 5-10 partsof radix puerariae and a proper amount of water. Compared with the prior art, the anti-alcoholic dew has homology of medicine and food, takes the corn peptide as a main component, can inhibit the absorption of alcohol by the stomach, increases the activity of ethanol dehydrogenase and acetaldehyde dehydrogenase in vivo, and promotes the metabolism and discharge of alcohol in vivo; alcohol compounds can be quickly decomposed by drinking the anti-alcoholic dew before or after meals, so that the symptoms of patients with severe alcoholic liver can be gradually improved, and the anti-alcoholic dew has good functions of dispelling the effects of alcohol and protecting the liver. Besides, all the components play a synergistic role, so that a good hangover alleviating and liver protecting effectis achieved, and the anti-alcoholic dew is non-toxic and harmless, and can improve the ADH activity of liver tissues, promote ethanol metabolism, accelerate the elimination rate of ethanol metabolites, reduce damage to tissues and cells, play a role in alleviating hangover and promoting awakening, and protect the liver.