2results about How to "Realize continuous reaction" patented technology

The utility model relates to reactor technical field, concretely is a kind of grignard reagent continuous flow reactor, including fixing frame, the upper surface of fixing frame is fixedly connected with bearing frame, the inner wall of bearing frame is fixedly installed with funnel bottle, the top of funnel bottle is fixedly installed with nitrogen balance mouth, the bottom of funnel bottle is fixedly communicated with double-jacket pipe through communicating pipe, the bottom of double-jacket pipe is fixedly communicated with liquid inlet, the surface of double-jacket pipe is fixedly communicated with heat exchange inlet, heat exchange outlet and liquid outlet respectively, the inner wall of fixing frame is fixedly installed with temperature display screen;The utility model is set up novel continuous flow reaction, can improve the security of whole reaction process, control the descending speed of magnesium grain simultaneously, further improve the efficiency of reaction, solve the problem that reaction process is very dangerous and reaction end control is more complex in traditional kettle type reaction synthesis due to the above characteristics of grignard reagent preparation.

This invention belongs to the field of organic synthesis technology and relates to a method for synthesizing 3,4-difluoro-2-methoxyphenylacetic acid, comprising the following steps: S1 Using 3,4-difluoro-2-methoxyaniline and a diazotizing reagent as raw materials, a diazotization reaction is carried out under the action of a copper catalyst and an inorganic acid to obtain the 3,4-difluoro-2-methoxyaniline diazonium salt; subsequently, a Sandmeyer reaction is performed with bromine to obtain 6-bromo-2,3-difluoroanisole; S2 The 6-bromo-2,3-difluoroanisole obtained in step S1 is reacted with diethyl malonate under the action of a ferricyanide to obtain 2-(3,4-difluoro-2-methoxyphenyl)malonic acid; S3 The 2-(3,4-difluoro-2-methoxyphenyl)malonic acid obtained in step S2 is reacted with concentrated sulfuric acid to obtain 3,4-difluoro-2-methoxyphenylacetic acid. This invention features mild reaction conditions, high yield, and high purity, making it suitable for industrial production.