The invention discloses a sparse electroencephalogram
signal source positioning method based on functional magnetic
resonance guidance, and relates to the crossing field of electroencephalogram
signal processing and
neuroimaging technologies. The method mainly comprises three parts of fMRI-guided sparse source space construction, subject specificity forward model construction and multi-target regularization inverse problem solving. The method comprises the following steps: firstly, screening high-activation voxels through BOLD
signal intensity of fMRI, and constructing a sparse source space through
connected component analysis and
representative point selection; then, a
subject specific boundary element (BEM)
head model is constructed based on the structural MRI, and
electrode registration and
lead field matrix calculation are completed; and then a multi-target regularization model fusing data fidelity, space compactness and intensity consistency is constructed,
optimal estimation of source current intensity is obtained through analysis and solution, and finally a positioning result of brain power activation is output. According to the method, the advantages of high
time resolution of the EEG and
high spatial resolution of the fMRI are fully played, the limitations of inverse problem morbidity, low spatial resolution and insufficient multi-mode fusion in traditional brain power supply positioning are effectively solved, and brain power supply positioning with high precision,
noise resistance and high
interpretability is realized; and a new scheme is provided for
cognitive neuroscience research,
nervous system disease diagnosis and brain-computer interface development.