This application discloses a method and related equipment for cortical
signal reconstruction based on a physically constrained
diffusion model. The method includes: acquiring non-invasive EEG signals from the head of a target subject; extracting conditional feature vectors from the non-invasive EEG signals; inputting the conditional feature vectors into a trained
diffusion model for denoising to obtain transient latent variables; obtaining transient ECoG estimates based on the transient latent variables and a trained physical-sensory variational
autoencoder; calculating a theoretical
signal based on the transient ECoG estimates and a preset
lead field matrix; updating the transient latent variables based on the difference between the theoretical
signal and the non-invasive EEG signal until a target
latent variable is obtained; the preset
lead field matrix represents the transmission relationship from the cortical source space to the
scalp sensor space; and obtaining the ECoG reconstructed signal based on the target
latent variable and the trained physical-sensory variational
autoencoder. The embodiments of this application can accurately predict ECoG using EEG. This application can be widely applied in the field of
electroencephalography (EEG) technology.