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Pseudomonas pseudoalcaligenes is an aerobic, Gram-negative soil bacterium that was first isolated from swimming pool water. It can also be found in cutting fluid. It is able to use cyanide as a nitrogen source, and as a result, it may be used for bioremediation. Based on 16S rRNA analysis, P. pseudoalcaligenes has been placed in the P. aeruginosa group.
Application of pseudomonas alcaligenes composition in preparation of pancreatic cancer treatment medicine
PendingCN122031681ABacteriaBacteria material medical ingredientsAntiendomysial antibodiesPancreas Cancers
The invention belongs to the field of tumor immunity, discloses application of a pseudomonas alcaligenes composition in preparation of pancreatic cancer treatment drugs, and aims to solve the technical problems that pancreatic cancer immunotherapy is low in response rate and existing treatment schemes are high in toxicity. The pseudomonas alcaligenes used in the invention are sPseudomonas alcaligenes, 4-carboxyphenylacetic acid and 1-(4-carboxybutyl) indole-5-boric acid are used as composite cross-linking agents, the composite cross-linking agents and sodium alginate form a hydrogel carrier, the pseudomonas alcaligenes are efficiently encapsulated, a PD-1 antibody is loaded, the tumor weight of the pancreatic cancer is remarkably reduced, tumor growth is effectively inhibited, and the pancreatic cancer can be effectively inhibited. The triple barriers of pancreatic cancer immunotherapy are successfully broken through; the hydrogel carrier is high in bacterial encapsulation efficiency, can effectively construct a growth microenvironment suitable for pseudomonas alcaligenes and promote bacterial growth, and is excellent in biological safety; and a low-toxicity and high-efficiency brand-new technical scheme is provided for immunotherapy of pancreatic cancer.
Owner:ZHEJIANG CANCER HOSPITAL