The invention discloses a distributed line loss determination and power grid monitoring equipment and method. The equipment comprises a main server, at least one second-level server connected with the main server and at least one third-level server connected with the second-level server, wherein the third-level server is at least connected with an external user terminal, the third-level server comprises an acquisition chip, a third-level metering module, a third-level memory, a third-level processing module and a third-level communication module, the second-level server comprises a second-level metering module, a second-level processing module, a second-level communication module and a second-level memory, and the main server comprises a communication module, a metering module, an analysis module, a monitoring module and a main memory. Data of the power grid can be conveniently acquired through three-level design, a line loss value can be acquired through calculation on the basis of the acquired data, the data is accurate, calculation is rapid, an abnormal data area can be found out through comparing an actual line loss value and a theoretical line loss value, an overhaul and maintenance instruction can be timely emitted, and power grid operation stability is improved.