The invention discloses a process method capable of improving the thermal fatigue property of a polynary zinc-aluminum alloy and belongs to the technical field of zinc-aluminum alloy preparation. The process method is characterized in that industrial aluminum ingots A00, zinc ingots 0, electrolytic copper, composite modifiers (wherein 20-30% of Ni, 15-25% of Ti, 5-15% of Mn, 5-15% of Cr, 5-10% ofSi, 5-10% of Ce, 5-10% of La, 1-6% of Y, 1-6% of Nb, 1-6% of V and the balance aluminum) and pure magnesium are used as raw materials. The method includes: proportionally weighing, by weight, 27-29% of Al, 2-2.5% of Cu, 0.2-1.2% of the composite modifiers, 0.01-0.02% of Mg and the balance Zn, melting the components in a medium-frequency induction melting furnace, pouring the melted zinc-aluminum alloy on common metal molds and vibratory metal molds, then processing the poured metal molds to test bars meeting national standards and sampling on blanks so that thermal fatigue testing specimens are processed by wire cutting.