A compound which can be attached to a
solid support and used as a
reagent for methods of
solid phase synthesis has the following structure: (I) where Ri is selected from
hydrogen and C1-C6
alkyl; R2 is selected from
hydrogen, hydroxy, and C1-C6 alkoxy, or together R1 and R2 form a
single bond; R3, R4, R5 and R6 are the same or different from each other and each represents
hydrogen, C1-C6
alkyl, and
halogen, or together R3 and R4 with R5 and R6 form an aromatic ring, further wherein the aromatic ring is substituted with one or more X; X is selected from
halogen, nitro, amino, and aminocarbonyl; s is 0, 1, 2, or 3, t is 0, 1, 2, or 3, wherein s+t≧1; R7 and R8 are the same or different from each other and each represents hydroxy,
halogen, hydrogen, C1-C6 alkoxy, oxyacyl, or together R7 and R8 form a carbonyl; Y is selected from a
methylene or substituted
methylene,
nucleoside,
nucleotide, protected
nucleoside, protected
nucleotide, C1-C6
aryl, arylalkyl, heteroalkyl, heterocycle, and heteroaryl; n is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10; Z is selected from OR and NHR; R is selected from hydrogen, SiRa, RbRc, CRaRb, Rc, heteroalkyl, and C1-C6
alkyl; Ra, Rb, and Rc are the same as or different from each other and each represents methyl, ethyl, i-propyl, t-butyl, phenyl or substituted phenyl.