The invention discloses anti-fouling and fingerprint-resistant stainless steel plate water-based paint and a preparation method thereof. The anti-fouling and fingerprint-resistant stainless steel plate water-based paint is prepared from, by weight, 55-70% of hydroxy modified waterborne polyester resin, 8-15% of methylated amino resin, 3-5% of modified silica sol, 2-4% of a neutralizing agent, 0.1-0.3% of a wetting agent, 0-0.2% of theological additives, 0.1-1.5% of a defoaming agent, 0.1-0.5% of a flattening agent, 3-6% of aqueous polyethylene wax and polytetrafluoroethylene wax mixed paste, 1-3% of an adhesive force promoting agent, 1-3% of nanometer inorganic salt, 0.2-0.5% of a catalyst, 3-5% of a cosolvent and 1-8.5% of deionized water. The anti-fouling and fingerprint-resistant stainless steel plate water-based paint has excellent fingerprint resistance and hydrophobicity and oleophobicity, and is large in fingerprint-resistant coating water contact angle and oil contact angle, small in sliding angle, and excellent in abrasion resistant and aging resistance, and greasy dirt is prone to sliding. Meanwhile, the anti-fouling and fingerprint-resistant stainless steel plate water-based paint is environmentally friendly and healthy, and the method is simple.