An organosilicon modified aqueous polyurethane resin comprises the following raw materials in percentage by weight: 10 to 20 percent of isocyanate, 20 to 40 percent of polyester polyol, 0.1 to 5 percent of organic silicon oil, 2 to 5 percent of a hydrophilic chain extender, 2 to 5 percent of a polyol chain extender, 1 to 3 percent of a polybasic amine chain extender, 0.01 to 1 percent of a catalyst, 1 to 4 percent of a salifying agent, 5 to 8 percent of a solvent and the rest of water. The emulsion made by the organosilicon modified aqueous polyurethane resin is obviously better than the emulsion made by a non-modified aqueous polyurethane resin regarding adhesion force, abrasion resistance, heat tolerance, smoothness, etc. The polyurethane emulsion made by the organosilicon modified aqueous polyurethane resin can be applied to the surface of a product through spray coating, brush coating, roller coating and dip coating. At present, the polyurethane emulsion is mainly used for the coating of the surfaces of gloves, condoms, medical ducts, etc.