The invention provides a traditional Chinese medicine prescription for treating primary liver cancer. The traditional Chinese medicine prescription is prepared from the following raw herbal materials: baical skullcap root, white paeony root, fritillary bulb, radix bupleuri, tree peony bark, fructus gardeniae praeparatus, tuckahoe, atractylodes macrocephala, officinal magnolia bark, dried orange peel, bitter almond, curcuma aromatica and liquorice. The traditional Chinese medicine prescription adopts traditional Chinese herbs as raw materials, and is prepared through the scientific prescription and repeated verification in experimental study and clinical trials, has the excellent curative effect on treating primary liver cancer, can effectively prolong the life time of patients, prevents recrudescence, improves life quality, realizes the purpose of healthy life in a long term, and is free of any toxic and side effects, high in efficacy, low in treating cost and easy for patients to accept.