The invention belongs to the technical field of measurement, and in particular relates to a full-pressure tiny leak precision measurement system which is composed of a ball valve, a stop valve, a three-way sealing valve, a high-precision differential pressure gauge, an instrument control unit, a timer, a vacuum pump, a constant volume chamber, a gas distribution chamber, a gas cylinder and a pipejoint. The ball valve is adopted to cause the constant volume chamber with a known volume to be connected with the gas distribution chamber through a pipe, the stop valve is used to be connected withthe high-precision differential pressure gauge, and the three-way sealing valve is connected with the vacuum pump. After a part to be measured, the high-precision differential pressure gauge, the constant volume chamber and the gas distribution chamber reach the pressure balance, the ball valve is switched off, the stop valve is switched on to enable tiny leaked gas to be introduced into the constant volume chamber through a pipe, the gas flows to the gas distribution chamber through the high-precision differential pressure gauge, and the accumulated pressure change of the part to be measuredover time can be obtained. The full-pressure tiny leak precision measurement system has the advantages of being convenient to operate, small in size, wide in measurement range, high in measurement precision, not subjected to interference of gas source medium, capable of performing full pressure measurement, convenient to carry and low in cost.