The invention discloses a water curtain paint spraying chamber. The water curtain paint spraying chamber comprises an overflow tank, a box-shaped frame, a water tank, a water replenishing tank, a high-pressure spraying plate, a spraying water tank, a circulating pump, a circulating loop, a gas-liquid separation bin, a draught fan and a water curtain device. The water curtain paint spraying chamber is characterized in that the overflow tank is fixedly installed on the top of the water curtain paint spraying chamber, the spraying water tank is installed under the overflow tank, and the water curtain device is located on the right side of the spraying water tank; a sliding block is slidably installed on a sliding rail, a hoisting device is fixedly installed under the sliding block, the spraying water tank is installed on the left side of the water curtain device, and the upper end of the spraying water tank is connected with the bottom of the overflow tank. According to the water curtain paint spraying chamber, the water curtain area is increased, the paint mist filtering procedure is optimized, and therefore air is filtered more thoroughly; meanwhile, water in the water tank is reutilized after being filtered, therefore, the processing cost is reduced, and water supply sources are reduced.