The invention belongs to the technical field of syringes, in particular suitable for a 
drug injection mode for animals, and discloses a pre-filled high-temperature sterilization 
syringe. The pre-filled high-temperature sterilization 
syringe comprises a tube cap, a needle tube, a push rod and a 
piston, wherein the part, near the 
handle end of the needle tube, of the needle tube is provided with a stop ring, and the front end of the needle tube is provided with an external thread; the tube cap is provided with an internal thread, and the tube cap and the needle tube are assembled through rotation of the threads; the outer 
diameter of the push rod is matched with the inner 
diameter of a 
handle, and the outer 
diameter of the 
piston and the inner diameter of the needle tube are in an 
interference fit for sealing; the stop ring is welded to the part, near the 
handle end of the needle tube, of the needle tube, and during 
assembly, the push rod runs through the inner hole of the handle and assembled with the 
piston so as to form a locking structure after 
assembly. According to the pre-filled high-temperature sterilization 
syringe, a filling 
machine is used to inject a certain amount of 
drug liquid through the top of the needle tube of the syringe, the tube cap and the needle tube are assembled through rotation of the threads so that sealing and locking can be achieved, and the syringe is delivered into a sterilization chamber for 
steam sterilization at a high temperature of 121 DEG C for 30 minutes.