The invention discloses a method for modifying a PVC (Polyvinyl Chloride) resin in advance, which comprises the following steps of: mixing PVC (Polyvinyl Chloride) resin powder or granules with a structural modifying agent and an addition agent under a stirring condition, and reacting for 0.1-72 hours in the temperature of 5-120 DEG C, wherein the structural modifying agent is selected from alkane with 1-6 atomic carbons, halogenated methane, halogenated ethane, halogenated propane, carbon dioxide, dimethyl ether, aliphatic alcohol with 1-4 atomic carbons and ketone with 3-5 atomic carbons; the addition agent is selected from fatty acid salt, alkyl group sulfate, alkyl sulfonate, alkylbenzene sulfonate, tetra alkyl halogenated ammonium, tetra alkyl ammonium hydroxide, a betaine ampholyticactive agent and a segmented copolymer of epoxy ethane and propylene oxide. The invention also discloses modified PVC (Polyvinyl Chloride) obtained by using the method, the application of PVC (Polyvinyl Chloride), a method for preparing modified PVC (Polyvinyl Chloride) by using the modified PVC (Polyvinyl Chloride) and the modified PVC (Polyvinyl Chloride) obtained therefrom. According to the invention, a aggregative state structure of a macromolecule chain inside the PVC (Polyvinyl Chloride) powder is changed by adopting a specific method so that the PVC (Polyvinyl Chloride) powder can be conveniently used for subsequent chemical modification or subsequent molding processing.