36 results about "In situ visualization" patented technology

A dense volumetric grid coming from an oil / gas reservoir simulation output is translated into a compact representation that supports desired features such as interactive visualization, geometric continuity, color mapping and quad representation. A set of four control curves per layer results from processing the grid data, and a complete set of these 3-dimensional surfaces represents the complete volume data and can map reservoir properties of interest to analysts. The processing results yield a representation of reservoir simulation results which has reduced data storage requirements and permits quick performance interaction between reservoir analysts and the simulation data. The degree of reservoir grid compression can be selected according to the quality required, by adjusting for different thresholds, such as approximation error and level of detail. The processions results are of potential benefit in applications such as interactive rendering, data compression, and in-situ visualization of large-scale oil / gas reservoir simulations.

The invention relates to an in-situ visualization method for the cavitation behavior of fused brazing filler metal in a solid liquid interface in ultrasonic-assisted brazing. The in-situ visualization method is suitable for the sizes of the brazing filler metal and base metal for synchrotron radiation imaging and the sandwiched coupled mode, and an ultrasonic field is applied through a high temperature-resistant ultrasonic vibration system capable of resisting 800 DEG C. The method comprises the steps of sample preparation; ultrasonic field application preparation; integral imaging equipment assembly; and visualization measurement of synchrotron radiation imaging of the cavitation behavior of the fused brazing filler metal. The method especially comprises the steps of ultrasonic field application in the high temperature environment, selection of the coupled mode of the sample base metal and the brazing filler metal and high temperature anti-oxidation treatment. The method is widely applied to the brazing filler metal of different temperatures and plays an important role in understanding and improving breaking oxidation films of the cavitation effect of ultrasonic-assisted brazing, promoting the moistening and spreading process of the brazing filler metal, revealing the acoustic-induced moistening physical mechanism of the brazing process of the brazing filler metal and the base metal (such as aluminum alloy and titanium alloy) and promoting industrial application of the ultrasonic-assisted brazing technology.

The present invention discloses an in-situ visualization method for trajectory data based on a stream data cube, and defines a data structure suitable for stream data. For a certain quantity of arrival trajectory data streams, processing and update of data can be completed in a very short period of time, thereby implementing real-time processing of data. In addition to the use of conventional grid division, an administrative region division method with more practical significance is introduced. The administrative region division method allows a query processing result generated from the visualization method provided by the present invention to have more practical value. The method disclosed by the present invention has the features of short data processing time and quick data update.

The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present invention thus relates to methods of detecting cancer in a sample, comprising utilising a glycopeptide bait derived from human mucins with different cancer-associated O-glycans. Detected antibodies were demonstrated as glycopeptide specific, and it could be discriminated between e.g. colorectal cancer patients and healthy individuals. The inventors have also developed monoclonal antibodies based on the identified glycopeptides epitope baits, and demonstrated differential expression of the relevant target antigens. The invention thus, in a lock and key-based manner includes both glycopeptides and antibody tools for early detection of cancer, as well as methods of using the same for in situ visualisation and treatment of specific cancer types.

The present inventors have demonstrated that circulating auto-antibodies to cancer antigens hold promise as specific and sensitive biomarkers for the early detection of cancer. The present invention thus relates to methods of detecting cancer in a sample, comprising utilising a glycopeptide bait derived from human mucins with different cancer-associated O-glycans. Detected antibodies were demonstrated as glycopeptide specific, and it could be discriminated between e.g. colorectal cancer patients and healthy individuals. The inventors have also developed monoclonal antibodies based on the identified glycopeptides epitope baits, and demonstrated differential expression of the relevant target antigens. The invention thus, in a lock and key-based manner includes both glycopeptides and antibody tools for early detection of cancer, as well as methods of using the same for in situ visualisation and treatment of specific cancer types.

The method includes novel applications for liposuction, lipectomy, liposculpting, and ultrasonic fat harvesting and emulsification devices, especially those devices that provide in situ visualization. The application includes immediately transferring harvested autologous fat from the liposuction, lipectomy, liposculpting, or ultrasonic device to an injector portion on the fat harvesting and emulsifying device or to a separate injector unit that injects it into muscle to provide a higher value, more desirable, use for and positioning of the fat in the form of muscle volume expansion.

The invention provides a method for controlling the hydrophilic modification effect inside a micro-fluidic chip, and belongs to the technical field of micro-fluidic chip hydrophilic control. The method is based on the specific and selective recognition effects of aggregation induction luminescent molecules modified by two boric acid groups and PVA containing hydroxyls, the fluorescence visual imaging labeling is performed inside the micro-fluidic chip subjected to hydrophilic treatment; the inside fluorescence intensity and distribution condition can be subjected to measurement and control condition analysis through a fluorescence microscope or a laser co-focusing microscope. The method has the advantages that the in-situ visual control on the micro pore passages in the micro-fluidic chipis realized; the problem that the in-situ detection cannot be realized on the inside of the chip in the conventional measurement can be solved; the method belongs to a safe, nondestructive, fast and effective visual recognition method, and can be widely applied to the materials to realize the fast screening on the hydrophilic treatment effects.

The invention relates to a visual in-situ analysis method of nitrocompound in soil. The method comprises the following steps: (1) slicing frozen soil microaggregate particle to obtain a micro-slice sample, and transferring the micro-slice sample onto a glass slide; (2) analyzing nitrocompound, different organic carbon morphologies and clay minerals constituents and microcell distribution in a to-be-detected micro-slice sample by utilizing a synchronous radiation Fourier transform infrared microscope imaging technology; and (3) performing spectrum unfolding on the measured data to obtain the occurrence form and microcell distribution spectrogram of the nitrocompound, different morphological organic carbon and clay minerals in the soil; analyzing the spectrogram to obtain a critical factor influencing the combination site and microcell distribution of the nitrocompound in the soil. The method has an intuitive effect, the visual observation of the nitrocompound in the soil is realized, and experiment evidence and theoretical support are supported for disclosing relevant reaction mechanism and repairing the polluted soil.

The invention discloses an in-situ visual determination method for enzyme activity in plants under environmental stress. The in-situ visual determination method comprises the following steps: plant pretreatment; enzyme spectrum imaging; standard curve production; and image processing. The invention provides the in-situ visual determination method of enzyme activity in plants under pollutant stress, and makes up the technical blank of plant leaf enzyme spectrum in the prior art. Meanwhile, by providing a series of image processing means, a leaf enzyme spectrum high-quality image is reconstructed, so that useful information of qualitative accuracy is improved, and the method has greater application prospects.

The invention discloses an in-situ visualization method of dispersity of an inorganic filler in plastic, belongs to the technical field of filler dispersity in plastic and relates to a method for special identification dyeing screening of an inorganic filler in plastic after film formation. Based on special identification of boronic acid-modified fluorescent molecules and surface hydroxyl of a layered filler, the inorganic filler in a press-molded plastic film is subjected to fluorescent labeling and through a fluorescence microscope or a confocal laser scanning microscope, the visualization result is measured and analyzed. The method is free of pre-modification or treatment on the inorganic filler, only utilizes immersion of any plastic film in boric acid fluorescent molecules, is an in-situ, non-destructive, rapid and effective visual identification method and can be widely used for effective screening of an inorganic filler in a composite material in the factory.

A dense volumetric grid coming from an oil / gas reservoir simulation output is translated into a compact representation that supports desired features such as interactive visualization, geometric continuity, color mapping and quad representation. A set of four control curves per layer results from processing the grid data, and a complete set of these 3-dimensional surfaces represents the complete volume data and can map reservoir properties of interest to analysts. The processing results yield a representation of reservoir simulation results which has reduced data storage requirements and permits quick performance interaction between reservoir analysts and the simulation data. The degree of reservoir grid compression can be selected according to the quality required, by adjusting for different thresholds, such as approximation error and level of detail. The processions results are of potential benefit in applications such as interactive rendering, data compression, and in-situ visualization of large-scale oil / gas reservoir simulations.

The invention discloses an immunity probe based on a polymer luminous point and a preparing method and application thereof.The preparing method includes the steps that CN-PPV and PSMA are reacted, and a PDs aqueous solution is prepared and obtained; the PDs aqueous solution, PBS and EDC are mixed to be even to obtain mixed liquid A; the mixed liquid A and phosmet antibodies are mixed and reacted, and the immunity probe based on the polymer luminous point is obtained.The immunity probe can specifically recognize phosmet, and therefore the immunity probe can be used for quantitatively detecting phosmet and self-quantitatively or quantitatively detecting phosmet.The qualitative and self-quantitative detecting method is an in-situ visual detecting method; the quantitative detecting method is high in sensitivity and specificity, and high-sensitivity quantitative detection can be carried out.

The invention discloses a fluorescent falsification-preventing gel with self-heating function, and a preparation method thereof. The molecule structure segment of the fluorescent falsification-preventing gel with self-heating function is represented by formula I, wherein PDMS is used for representing polysiloxane chain segments, AIEgen is used for representing an aggregation induction luminescence unit with fluorescent function. The invention also discloses applications of the fluorescent falsification-preventing gel in the field of information safety false prevention, and self-healing process fluorescence visualization. The fluorescent falsification-preventing gel is colorless and transparent under daylight; under ultraviolet excitation, emitting of a plurality of colors including red, green, and blue can be realized; and the film of the fluorescent falsification-preventing gel is capable of displaying in-situ visual gel self heating dynamic process through fluorescent spectrum technology.

The invention discloses an in-situ visualization system of X-ray fluoroscopy imaging and a calibration method thereof. By adopting the in-situ visualization system of X-ray fluoroscopy imaging and thecalibration method thereof, an acquired fluoroscopy image is projected on the surface of an imaging object according to an original X-ray path; an operator can acquire internal image information of the object simply by viewing fluoroscopy image projection on the surface of the object. According to the in-situ visualization system of X-ray fluoroscopy imaging and the calibration method thereof, acalibration device and a first optical tracking system tool are adopted to determine the position and main optical axis of an X-ray source, then, a second optical tracking system tool, a third opticaltracking system tool and a spatial position pick-up tool are adopted to determine the position and main optical axis of a projection reflection device, after the position and main optical axis of theX-ray source and the position and main optical axis of the projection reflection device are uniformly converted to the same coordinate system, aligning is conducted, the projection field angles are further unified, image directions are aligned, and therefore the calibration of the X-ray source and the calibration of the projection reflection device can be conveniently completed.

The embodiment of the invention discloses a molten salt electrochemical multifunctional in-situ characterization device and a use method, and belongs to the technical field of high-temperature electrochemical analysis. The device provided by the invention can simultaneously support integration of in-situ Raman, in-situ optics and in-situ synchrotron radiation scanning, and can realize high-temperature melt structure analysis, in-situ visual display of the three-dimensional morphology of the electrode and deep and comprehensive understanding of the corresponding evolution process. The device is specifically composed of a vacuum heat preservation furnace body and a transparent electrolytic cell, and the vacuum heat preservation furnace body achieves three functions by designing a concave Raman corner objective lens inlet, an optical visualization window, a light supplementing window, an aluminum foil transmission window, a transparent quartz hearth, a two-section heating resistance wire and other systems. According to the transparent electrolytic bath, a furnace tube and a crucible of a conventional vertical resistance furnace are integrated, the crucible is connected with a rotating table at the bottom of a furnace body through machining, then the electrolytic bath rotates along with rotation of the rotating table in the testing process, and an electrode fault picture is obtained.

A method and kit for selectively labeling S-nitrosylated cysteines in proteins with a fluorescent tag. The method offers femtomolar sensitivity for the detection, quantification, in situ visualization, and a means for site-specific identification of S-nitrosylation events.

The invention relates to a preparation method and application of a fluorine-19 magnetic resonance imaging probe for sulfydryl detection. The structure and composition of the probe is as shown in the specification, wherein x is an integer from 5 to 50, and y is an integer from 5 to 50. The probe is a novel <19>F magnetic resonance imaging nano probe which uses redox response to activate amino protonation and is used for detecting in-vivo sulfydryl. The nano probe has the advantages that the nano probe is high in selectivity to sulfydryl compounds, and a detection signal can be easily analyzed and processed; meanwhile, the nano probe is high in sensitivity, simple to operate, small in tissue damage, high in resolution and the like, and an important means is provided for the real-time and in-situ visual monitoring of the in-vivo sulfydryl compounds.

The invention discloses a fluorescent blotting membrane for in-situ visual detection of root exudates as well as preparation and application of the fluorescent blotting membrane. The preparation method comprises the following steps: by taking cadmium telluride quantum dots as a fluorescence detection source, including the cadmium telluride quantum dots in a molecularly imprinted polymer which takes single plant root exudates as a template, aminopropyl siloxane, phenyl siloxane and a cross-linking agent, and finally loading the molecularly imprinted polymer on a gel membrane to prepare the fluorescent imprinted membrane for in-situ visual specific detection of chlorogenic acid. The fluorescent blotting membrane can be used for in-situ visual detection of plant root exudates, can only perform specific response on specific exudates in a complex system, and is high in specific response value, safe, non-toxic and reusable.

The invention discloses an in-situ visualization method for large-scale fluid simulation based on a super computer. The in-situ visualization method comprises the following steps: 1, obtaining grid data and flow field data xg and xw of a key time step from a simulation program of computational fluid mechanics; 2, completing the compression of the density rho, the X-momentum rho-u, the Y-momentum rho-v, the Z-momentum rho-w and the total energy p in the flow field data xw through a data compression technology; 3, transmitting the grid data xg and the flow field data xw to a visualization program and decompressing; 4, reasonably distributing the data to different nodes for visualization according to a data segmentation algorithm; and 5, combining the partitioning results obtained in the previous step, drawing a complete visualization result, and continuing the step 1 to obtain the related data of the next key time step, thereby realizing the in-situ visualization process of the large-scale fluid data.

The invention belongs to the field of biological target positioning. In order to solve the problems that the boundaries of biological targets cannot be accurately identified and the biological targets cannot be marked in situ, a positioning method and system for in-situ visual positioning of biological targets are provided, which can It can accurately locate, identify, protect and determine the boundary of biological targets in real time and efficiently. Among them, the in-situ visual positioning method of biological targets includes collecting the fluorescence emitted by the fluorescent groups of biological targets in real time to form a fluorescent image of biological targets; processing the fluorescent images of biological targets to obtain images containing only biological targets and clear boundaries ; Adjust the optical path of the projection beam projected to the biological target to be coaxial with the fluorescent optical path emitted by the biological target, and project the image containing only the biological target and with clear boundaries in real time and in situ in equal proportions to the biological target area emitting fluorescence.

The invention discloses a fluorescent imprinting membrane for in-situ visual detection of root exudates and its preparation and application. The invention uses cadmium telluride quantum dots as a fluorescence detection source, and incorporates them into a molecularly imprinted polymer with a single plant root exudate as a template, aminopropylsiloxane, phenylsiloxane and a cross-linking agent, Finally, it was loaded on a gel membrane to prepare a fluorescent blotting membrane for in situ visualization and specific detection of chlorogenic acid. The obtained fluorescent blotting membrane can visually detect exudates from plant root exudates in situ, can only respond specifically to specific exudates in a complex system, has a high specific response value, is safe, non-toxic, and can be reused.

The embodiment of the present invention discloses a molten salt electrochemical multifunctional in-situ characterization device and its use method, which belong to the technical field of high temperature electrochemical analysis. The device of the invention can simultaneously support in-situ Raman, in-situ optical and in-situ synchrotron radiation scanning in one body, and can realize structural analysis of high-temperature melts, in-situ visualization of electrode three-dimensional morphology, and in-depth and comprehensive understanding of the corresponding evolution. process. The device is specifically composed of a vacuum insulation furnace body and a transparent electrolytic cell. The vacuum insulation furnace body is designed with a concave Raman corner objective lens entrance, an optical visualization window, a supplementary light window, an aluminum foil transmission window, a transparent quartz furnace, and two-stage heating. The resistance wire and other systems realize the above three functions; while the transparent electrolytic cell integrates the furnace tube and the crucible of the conventional vertical resistance furnace, and realizes the connection between the crucible and the rotary table at the bottom of the furnace through processing, and then realizes the test process. The electrolyzer rotates with the rotation of the turntable, and the tomographic picture of the electrode is obtained.

The invention provides a method for controlling the hydrophilic modification effect inside a micro-fluidic chip, and belongs to the technical field of micro-fluidic chip hydrophilic control. The method is based on the specific and selective recognition effects of aggregation induction luminescent molecules modified by two boric acid groups and PVA containing hydroxyls, the fluorescence visual imaging labeling is performed inside the micro-fluidic chip subjected to hydrophilic treatment; the inside fluorescence intensity and distribution condition can be subjected to measurement and control condition analysis through a fluorescence microscope or a laser co-focusing microscope. The method has the advantages that the in-situ visual control on the micro pore passages in the micro-fluidic chipis realized; the problem that the in-situ detection cannot be realized on the inside of the chip in the conventional measurement can be solved; the method belongs to a safe, nondestructive, fast and effective visual recognition method, and can be widely applied to the materials to realize the fast screening on the hydrophilic treatment effects.

The invention discloses a particle data processing method, device and system based on in-situ visualization. The method is applied to a computing terminal and comprises the steps of obtaining to-be-processed original particle data; processing the original particle data based on a probability density function to obtain a target parameter; and transmitting the target parameter to a visual terminal,wherein the target parameter is used for being restored into target particle data on the visual terminal through a probability density function, and the difference value between the target particle data and the original particle data is smaller than a target threshold value, and the target parameter is used for performing visual processing on the visual terminal. According to the invention, the effect of effectively processing the particle data is achieved.

The invention discloses an in-situ visualized analysis method of an organic bromine compound in soil. The in-situ visualized analysis method comprises the steps of (1) contaminating soil by an organic bromine compound, selecting water saturated microaggregate of the soil, slicing a frozen microaggregate particle to obtain a micro slicing sample and transferring the sample onto a glass slide, (2) analyzing the composition and microcell distribution of carbonic functional groups and clay minerals in the micro slicing sample of the soil to be detected by a synchrotron radiation Fourier transformation infrared micro-imaging technology, (3) analyzing the same area, detected by the synchrotron radiation Fourier transformation infrared micro-imaging technology, of the micro slicing sample by a hard X-ray micro-focusing fluorescent micro-imaging technology, and analyzing the distribution of a tracer element Br and other mineral elements in the area to be detected and the occurrence modes of other mineral elements and Br, and (4) respectively obtaining microcell distribution spectrograms of the carbonic functional groups, the clay minerals, Br and the other mineral elements in the analysis area, and analyzing the spectrograms to obtain the microcell distribution character, related influence factors and other information of the organic bromine pollutant in the soil.

The invention relates to a core-shell nano-medicine for in situ visualized treatment of tumors, which belongs to the technical field of nano-medicine. The present invention adopts the nanoparticle formed by assembling the CpG OND labeled with the fluorescent probe and the polycationic compound as the inner core, and self-assembles the graphene quantum dot and photosensitizer copolymerization product modified by polydopamine surface on the inner core surface as the outer shell, and The MRI ion contrast agent is further chelated on the shell to form a core-shell nanomedicine. The nanomedicine of the present invention not only has excellent photodynamic / photothermal anticancer effect and good immune stimulation effect, but also can perform lesion imaging through MRI imaging contrast agent and fluorescent probe, has visualization characteristics, and realizes non-invasive real-time tracking of nano The distribution, absorption and metabolism of drugs can be further used for prognostic detection. The nano-medicine of the invention integrates combined therapy and multimodal imaging diagnosis functions, realizes the integration of tumor diagnosis and treatment, and has broad application prospects in the field of tumor diagnosis and treatment.

The present invention is directed to a system and method for enhancing in situ visualization of a target site within a patient during a medical procedure using fluorescence. As such, the system includes a plurality of fluorescent molecules configured to selectively target and bind to one or more locations at the target site within the patient and a delivery mechanism for delivering the fluorescent molecules into the patient. In addition, the system includes a detection device configured to generate a detectable signal containing information relating to the target site and send the detectable signal to an imaging system for viewing by a user, such as a physician. Thus, the fluorescent molecules enhance in situ visualization of the target site when viewed through the skin of the patient.

The invention discloses an in-situ visualization system of X-ray fluoroscopy imaging and a calibration method thereof. By adopting the in-situ visualization system of X-ray fluoroscopy imaging and thecalibration method thereof, an acquired fluoroscopy image is projected on the surface of an imaging object according to an original X-ray path; an operator can acquire internal image information of the object simply by viewing fluoroscopy image projection on the surface of the object. According to the in-situ visualization system of X-ray fluoroscopy imaging and the calibration method thereof, acalibration device and a first optical tracking system tool are adopted to determine the position and main optical axis of an X-ray source, then, a second optical tracking system tool, a third opticaltracking system tool and a spatial position pick-up tool are adopted to determine the position and main optical axis of a projection reflection device, after the position and main optical axis of theX-ray source and the position and main optical axis of the projection reflection device are uniformly converted to the same coordinate system, aligning is conducted, the projection field angles are further unified, image directions are aligned, and therefore the calibration of the X-ray source and the calibration of the projection reflection device can be conveniently completed.

Kinases can be engineered to utilize an ATP analog that is not readily utilized by wild-type kinases by introducing a mutation in the ATP-binding pocket. However, application of this method has been limited by the membrane impermeability of the ATP analog. Provided herein are methods for in situ visualization of substrates of an analog-sensitive kinase, the method comprising a mild fixation step. Also provided herein are kits comprising a fixative, an ATP analog, and an agent for detecting the substrates modified by the ATP analog.