The invention discloses a high-strength anti-collapsing petroleum casing column. The casing column comprises the following chemical elements in percentage by mass: 0.24-0.30 percent of C, 0.9-1.3 percent of Mn, 0.25-0.50 percent of Si, 0.9-1.3 percent of Cr, 0.6-0.8 percent of Mo, 0.06-0.10 percent of V, 0.01-0.03 percent of Al, 0.02-0.05 percent of Nb, 0-0.03 percent of Zr, less than 0.004 percent of B, less than 0.03 percent of Ti, less than 0.015 percent of P, less than 0.010 percent of S, 0.001-0.006 percent of Ca, and the balance of Fe and inevitable impurities, wherein Ca/S ratio is more than 1; the external diameter size Phi of the casing column is 141.3 mm to 142.7 mm; and the wall thickness of the casing column is 10.7 mm to 12.9 mm. Correspondingly, the invention further provides a manufacturing method of the casing column.