The invention belongs to the technical field of alloy steel and particularly relates to a heat treatment method for high-temperature alloy steel. The heat treatment method comprises the steps of a, a high-temperature diffusion annealing process, wherein a high-temperature alloy steel ingot is heated for 22-26 h at the temperature of 1,150 plus or minus 10 DEG C, then heating is conducted for 70-74 h at the temperature of 1,190 plus or minus 10 DEG C, and then air cooling is conducted; b, pretreatment after forging, wherein the heating temperature is 950 plus or minus 10 DEG C, the temperature is kept for 0.5-1.5 h, and then air cooling is conducted; c, high-temperature solid solution treatment, wherein the heating temperature is 910 plus or minus 10 DEG C, the temperature is kept for 18-24 h, and then air cooling is conducted; and reheating is conducted, the heating temperature is 960 plus or minus 10 DEG C, the temperature is kept for 1-2 h, and air cooling is conducted; and d, low-temperature aging treatment, wherein the heating temperature is 710 plus or minus 10 DEG C, the temperature is kept for 7-10 h, then the temperature is decreased to 610 plus or minus 10 DEG C at the speed of 50-60 DEG C/h with furnace cooling, then the temperature is kept for 7-10 h, air cooling is conducted, and a forging is obtained. By the adoption of the heat treatment method for the GH4169 high-temperature alloy steel, the heating pretreatment after forging, high-temperature solid solution treatment and low-temperature aging treatment thermal treatment process system is adopted, the high-temperature plasticity is good and the creep resistance life is long.