The invention discloses a production method of an HRB500E fine-grain high-strength anti-seismic anti-corrosion reinforcing steel bar. The method comprises the following steps of converter smelting, deoxidizing alloying, LF refining, square billet continuous casting, steel billet heating, rolling and cooling in sequence to produce the fine-grain high-strength anti-seismic anti-corrosion reinforcing steel bar which is stable in quality, excellent in plasticity and toughness, greater than 1.27 in yield ratio and 11.5-12.0 in ferrite grain size. The Cr, V and Ni composite microalloying process is adopted, converter smelting and LF external refining are matched, the rolling technology for controlling the inner diameter and negative deviation of the reinforcing steel bar at low temperature is adopted, finishing is combined, formation and precipitation of a fine and dispersed microalloy carbon (nitrogen) compound second phase are promoted, the steel strength is improved, meanwhile, the plasticity and toughness are remarkably improved, mechanical connection is further facilitated, reasonable matching of high strength, obdurability, low strain timeliness, shock resistance and corrosion resistance of the reinforcing steel bar is achieved, and the method can be applied to the fields of main stream hydropower station flood discharge tunnel engineering, expressway road and bridge engineering and the like.