The invention relates to a formula of fluorine rubber and epichlorohydrin rubber. The components of the inner layer of fluorine rubber include fluorine rubber, thermal black N990, 2,5-dimethyl-2,5-dihexane, triallyl cyanurate, carnauba wax; the middle layer and the outer layer The components of the layer epichloride rubber include epichloride rubber C, epichloride rubber H, quick extruded carbon black N550, anti-aging agent NBC, processing aid R-300, stearic acid, plasticizer RS-107, trioxide Lead, ethylenethiourea NA-22, plasticizer W-305ELS, anti-scorch agent CTP-80. By adopting the rubber hose whose inner layer is fluorine rubber and outer layer is chloroether rubber, the problems of high temperature resistance, heat oil resistance, ozone resistance, and fuel oil permeation requirements of the fuel hose are improved.