The invention discloses a high-strength water-resistant odorless putty powder and a preparation process thereof, and belongs to the technical field of building materials, wherein the high-strength water-resistant odorless putty powder comprises the following raw materials: modified heavy calcium carbonate, kaolin, ash calcium powder, white cement, modified talc powder, bentonite, a high water absorption resin, a natural resin, lignocellulose, polypropylene cellulose, redispersible latex powder, polyvinyl alcohol, sodium carboxymethyl cellulose, murraya paniculata powder, hedera nepalensis powder, bamboo charcoal fiber, pomelo peel powder, seaweed soil, a whitening agent, an auxiliary agent, an antifoaming agent, a preservative, and a retarder. According to the present invention, the high-strength water-resistant odorless putty powder is prepared through mixing, stirring, grinding and other steps, has strong water resistance, cannot produce hollowing and peeling after being wet, has characteristics of refreshing odor, formaldehyde absorbing, health benefiting and long service life, can be organically combined with various coating materials, and has broad application value and marketprospects.