34results about How to "Simple and safe process operation" patented technology

The invention relates to a method for removing sulfur in petroleum coke and a desulfurizer thereof. The method adopts two types of mixed acid with a fixed ratio controlled as the desulfurizer, and comprises the following steps: placing fine petroleum coke with a high S content (the S content being 3-7 percent) in the mixed acid under the atmospheric pressure and the temperature of 0-60 DEG C, soaking the petroleum coke for reaction for a certain time, separating the petroleum coke and the soaking solution, washing and drying. The desulfurization percent of the obtained petroleum coke is 45-60 percent, the microstructure of the petroleum coke is not changed obviously, and the separated soaking solution of mixed acid can be repeatedly used when being mixed with the newly prepared liquid. The method has the advantages of low desulfurization cost, simple operation and significant desulfurization effect.

The invention discloses a synthesis method of perfluoroisobutyronitrile, comprising the following steps of: (1) carrying out a reaction between oxalyl chloride monoester and fluoride salt in a solventto obtain oxalyl fluoride monoester; (2) carrying out a reaction between oxalyl fluoride monoester and hexafluoropropylene in a solvent by taking fluoride salt as a catalyst to prepare heptafluoro-2-carbonyl-3-methylbutyrate; (3) carrying out catalytic decarbonylation on heptafluoro-2-carbonyl-3-methylbutyrate in a solvent through cesium fluoride, so as to obtain heptafluoroisobutyrate; and (4) carrying out a reaction between heptafluoroisobutyrate and ammonia, and dehydrating to obtain perfluoroisobutyronitrile. The synthetic method has the advantages of easily available raw materials, mildreaction conditions, high raw material conversion rate and product yield, safe and simple process operation, and easy realization of industrial production.

The invention discloses an environment-friendly water-based automobile shellac cleaning agent. The environment-friendly water-based automobile shellac cleaning agent consists of the following components: fatty alcohol-polyoxyethylene ether phosphate, limonene, fatty acid diethanol amide, sodium carbonate and deionized water. The cleaning agent is prepared by compounding various non-toxic surfactants with excellent biodegradability and aids, has obvious synergistic effect among the components, can effectively remove shellac dirt form the surface of the automobile and has a good anti-rust effect on metal. The production method is simple to operate and low in production cost, and has good environmental and economic value.

The invention provides a medical titanium implant micro-arc oxidation film layer and a preparation method. The medical titanium implant micro-arc oxidation film layer comprises a matrix and an oxidization film layer formed on the surface of the matrix, wherein a plurality of micro holes are distributed in the surface of the oxidization film layer; the micro holes consist of a plurality of micro bosses and grooves; the bosses are inwards sunken to form concave holes; the grooves are distributed in the peripheries of the bosses; the bosses are protruded relative to the grooves; the grooves are in an irregular state; the adjacent grooves are communicated with each other; and the oxidation film layer has color. The film layer provided by the invention has hydrophilicity, high-strength binding force and color. The medical titanium implant micro-arc oxidation film layer is simple in operation and preparation process, is relatively low in cost, and the obtained film layer is excellent in performance, and is suitable for industrial production.

The invention discloses a preparation method of tetraethyl methylene diphosphate, comprising the following steps: 1) under the action of sodium ethoxide, diethyl phosphite reacts with sodium ethoxide to obtain sodium diethyl phosphite ethanol solution , ethanol is removed by distillation under reduced pressure to obtain sodium diethyl phosphite solid; 2) dichloromethane is added to the solid sodium diethyl phosphite obtained in step 1); sodium diethyl phosphite and dichloromethane are substituted After the reaction, tetraethyl methylene diphosphate was obtained. The preparation method of the invention has mild and simple reaction conditions and high yield at the same time. The method is simple to operate and low in energy consumption, and is suitable for industrial production.

The invention relates to a method for producing a flame-retardant fiber from a vinylon production line and an obtained flame-retardant fiber. The method comprises the following steps: a) dissolving polyvinyl alcohol in water so as to obtain a spinning solution; b) adding an aqueous solution of a tetrahydroxymethyl phosphorus compound; c) spinning by using a mirabilite wet method, and performing condensation and stretching so as to obtain a primary fiber; d) drying the primary fiber obtained in the step c) so as to obtain a flame-retardant precursor fiber; e) performing ammonia fumigation on the flame-retardant precursor fiber obtained in the step d) so as to obtain an ammonia fumigation fiber; f) oxidizing the ammonia fumigation fiber obtained in the step e); and g) randomly performing washing, oiling and drying, thereby obtaining the flame-retardant fiber.

The invention discloses a synthetic method of anti-tumor molecular targeted drug crizotinib, belongs to the field of pharmaceuticals, and relates to a synthetic method of a crizotinib intermediate. The method comprises two reduction processes: a bromination reaction process comprises the following reaction steps: a reduction process I: carrying out reduction reaction on a (R)-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxyl]-2-nitropyridine compound and sodium dithionate under a mechanical chemical condition to generate (R)-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxyl]-2-aminopyridine; a reduction process II: dissolving the (R)-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxyl]-2-nitropyridine compound into an organic solvent, carrying out catalytic hydrogenation and reduction treatment to generate (R)-3-[1-(2,6-dichloro-3-fluorophenyl)ethoxyl]-2-aminopyridine; the bromination reaction process comprises a step of carrying out reaction between the compound and potassium hydrogen persulfate as well as bromate to obtain the crizotinib intermediate. The process is low in cost, the raw materials are easy to purchase, the operation is simple, convenient and safe, and the yield is high; moreover, the process is suitable for large-scale production.

The invention discloses a method for preparing long-chain fluoroalkylsiloxane. According to the method, long-chain fluoroalkylethylene and alkoxy silane are used as raw materials to prepare the long-chain fluoroalkylsiloxane through hydrosilylation. The method is characterized in that a hexafluoroisopropanol solution of chloroplatinic acid is used as a catalyst and the dosage of a platinum catalyst is 10<-5> to 10 <-4> of the molar amount of the alkoxy silane. The method comprises the following steps: under the protection of nitrogen, adding hexafluoroisopropanol into chloroplatinic acid hexahydrate to completely dissolve chloroplatinic acid so as to prepare a chloroplatinic acid/hexafluoroisopropanol solution with a concentration of 1-10 mM; sequentially adding alkoxy silane, long-chain fluoroalkylethylene and the prepared chloroplatinic acid/hexafluoroisopropanol solution into a reactor, and conducting reacting at 40-80 DEG C for 30-60 minutes; and carrying out reduced-pressure distillation on reaction liquid to obtain the target product, namely long-chain fluoroalkylsiloxane. The method is simple in process, mild in reaction conditions and high in product yield and purity.

The invention relates to a method for preparing a key intermediate 4-methyl-5-ethoxazole of vitamin B6 and belongs to the technical field of crude drug preparation. The method for preparing 4-methyl-5-ethoxazole comprises the steps that firstly, 4-methyl-5-ethyoxyl-1,3-oxazole-2-nonanoic acid-ethyl ester, methylbenzene, drinking water and sodium hydroxide are sequentially put into a hydrolysis reaction still according to a certain proportion, and stirring, heat preservation and reacting are carried out; liquid separation is carried out, and the pH value of the water phase is adjusted to rangefrom 1.0 to 2.5; an organic solvent is added to the system obtained in the second step, reacting is carried out by controlling the temperature ranging from 30 DEG C to 50 DEG C until no carbon dioxideis generated; after decarboxylation is finished, the pH value is adjusted to be larger than or equal to 9.0, liquid separation is carried out, the organic phase is subjected to vacuum distillation, and 4-methyl-5-ethoxazole is obtained. The process is easy and safe to operate, and industrial production is easy.

The invention provides a method for continuously extracting durene from coal-sourced aromatic hydrocarbon. The method comprises the steps: adding a coal-sourced aromatic hydrocarbon raw material intoa primary distillation tower, separating light components such as trimethylbenzene in the raw material from the top of the primary distillation tower by utilizing the negative pressure inside the primary distillation tower, and placing the light components into a light component storage tank by a heat radiator; making a residual tower bottom in the primary distillation tower enter a rectifying tower to obtain a durene-enriched solution with the mass percentage of 90%-95% at the top of the rectifying tower; and storing the durene-enriched solution into a middle durene storage tank, and then, delivering the durene-enriched solution into a multistage crystallizer for fractional crystallization to refine durene with the purity of 99% or above. By using the method, the purity of durene can be increased to 99% or above, a product is a white powdery/sheet-like crystal, and the conversion ratio of the product can be increased by 5%-10% during downstream pyromellitic dianhydride processing. Compared with a traditional freezing-centrifuging-squeezing process, the method is simple and safe in process operation and low in energy consumption and risk; and the method can be used for processing durene with different contents according to market demands, so that the market demands are met.

The invention relates to a preparation method of soft biomass automobile washing liquid and belongs to the technical field of automobile cleaning and care articles. Milk fat is hydrolyzed under the acidic environment to produce higher fatty acid, the higher fatty acid is reduced into higher fatty acid alcohol under the action of reducing oxalic acid, the higher fatty acid alcohol reacts with glucose at high temperature to generate glycerinum and decyl glucoside, elements such as nitrogen, sulfur and phosphorus in chicken liver extracting liquid and the glycerinum are subjected to synergistic action to form one layer of chemical protective film on the surface of an automobile body to protect the automobile body and have a glazing effect, lecithin in yolk and the decyl glucoside serving as surfactants have strong detersive powder and rich foam and are fine and stable, and tea saponin and tea polyphenol in the tea extracting liquid have oxidation resistance and can improve the storage stability of the automobile washing liquid. The automobile washing liquid prepared by the method has obvious synergistic effect, is non-toxic, low in irritation and rapid and complete in biodegradation, avoids corrosion to the automobile body, and has excellent application prospect.