The invention discloses medicinal and edible solomonseal rhizome and Chinese wolfberry wine and a preparation method thereof. The solomonseal rhizome and Chinese wolfberry wine is prepared from Chinese liquor, solomonseal rhizomes, Chinese wolfberry fruits, longan aril, licorice, mulberries, cinnamon, ginseng, dried tangerine peel, honeysuckles and lotus seeds. By utilizing the synergistic effectof the components of the Chinese wolfberry fruits, the honeysuckles and the like, the effects of the Chinese wolfberry fruits on anti-aging, anti-mutation and anti-tumor as well as the honeysuckles onclearing away heat and toxic materials, resisting inflammation and tonifying deficiency are exerted to the maximum extent, so that the solomonseal rhizome and Chinese wolfberry wine has good curativeeffects of nourishing the body, nourishing yin and suppressing yang, invigorating qi and nourishing blood, strengthening the body constitution and prolonging life, has no toxic or side effect on thehuman body, does not generate dependence on the human body, and has the effect of homology of medicine and food. The solomonseal rhizome and Chinese wolfberry wine has the advantages of homology of medicine and food, safe eating, no toxic and side effects, simple preparation process, and low cost. The solomonseal rhizome and Chinese wolfberry wine is especially suitable for people with excessive thought, insomnia, amnesia, anorexia, asthenia, spleen qi deficiency or deficiency of both qi and yin, soreness of waist and knees, deficiency of liver and kidney yin, premature senility and the like.