3 results about "Folch solution" patented technology

The present invention provides a cleaning composition containing alkaline electrolyzed water, which facilitates the production of a diluted solution having a predetermined pH. [Solution] A cleaning composition is provided which contains bromothymol blue, thymol blue, or phenolphthalein as a pH indicator, and alkaline electrolyzed water having a pH of 12 or higher.

The invention discloses a method for detecting related substances of dapagliflozin tablets, and belongs to the technical field of medicine detection. The related substances comprise an impurity 383-1D, an impurity 383-1E, an impurity 383-1F and an impurity 383-1G, and the detection method comprises the following detection conditions: adopting a high performance liquid chromatography method, taking octadecyl silica gel as a chromatographic column, taking potassium hydrogen phosphate as a buffer solution, taking acetonitrile as a diluted solution, taking a methanol-water solution as a mobile phase A, taking an acetonitrile-water solution as a mobile phase B, carrying out gradient elution, and carrying out gradient elution to obtain the impurity 383-1D, impurity 383-1E, impurity 383-1F and impurity 383-1G. And separating the related substances of the dapagliflozin tablet, and detecting to obtain the amount of the related substances. By detecting the amount of related substances, the production of the related substances in the production process is controlled, so that the product quality of the medicine is guaranteed.

The invention discloses a nano compound (RAP (at) KTP (at) AuNPs) for delivering rapamycin based on targeted peptide modified gold nanoparticles as well as a preparation method and application of the nano compound. In the nano compound, the surfaces of the gold nanoparticles are modified by polyethylene glycol to form a PEG layer; the K3 targeting peptide is connected to the surface of the PEG layer through non-covalent coupling; rapamycin is loaded and wrapped in the PEG layer. SH-PEG-SH is added into the AuNPs solution, and a PEG modified AuNPs solution is obtained through a reaction; diluting the K3 targeting peptide with pure water to obtain a diluted solution, adding the diluted solution into the PEG-modified AuNPs solution, and reacting to obtain a KTP-coated AuNPs solution; the preparation method comprises the following steps: dissolving rapamycin powder by using dimethyl sulfoxide, adding the rapamycin powder into a KTP (at) AuNPs solution, and reacting to obtain the nano-composite RAP (at) KTP (at) AuNPs. The nanocomposite provided by the invention can realize efficient and accurate delivery of rapamycin, and improves the effect of treating renal fibrosis.