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39 results about "Vibrio Infections" patented technology
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Infections with bacteria of the genus VIBRIO.
Recombinant OmpK multi-epitope polypeptide, construction method and application thereof
ActiveCN108530522AImprove the immunityImproving immunogenicityAntibacterial agentsDepsipeptidesInfectious DisorderNucleotide
The invention relates to the field of biomedicines and in particular relates to a recombinant polypeptide, a construction method and application thereof. More specifically, the invention provides a recombinant OmpK multi-epitope polypeptide and encoded nucleotide, carriers, cells and vaccines thereof, and application of the recombinant OmpK multi-epitope polypeptide to products of preventing vibrio infections. An experiment proves that the recombinant OmpK multi-epitope polypeptide or derivatives and vaccines thereof have the characteristics of safety and high efficiency and have very high immunogenicity on vibrio parahaemolyticus; animals immunized by the multi-epitope polypeptide contain a lot of specific antibodies and the effective protection rate on the immunized animals reach 90 percent or more; the recombinant OmpK multi-epitope polypeptide has the effect of improving the resistance capability of the animals immunized by the multi-epitope polypeptide on the vibrio parahaemolyticus; the recombinant OmpK multi-epitope polypeptide has a good immune protection effect and has great significance in the aspect of preventing and controlling infectious diseases of aquatic animals.
Owner:中华人民共和国汕头海关
SNP marker for distinguishing ability of litopenaeus vannamei against vibrio harveyi infection and detection method thereof and application of SNP marker
ActiveCN110791571AQuick checkAccurate detectionMicrobiological testing/measurementDNA/RNA fragmentationAntibiosisNucleotide
The present invention discloses a SNP marker for distinguishing ability of litopenaeus vannamei against vibrio harveyi infection and a detection method thereof and an application of the SNP marker. The SNP marker is located at the 1191th site of a Lyz-I2 gene sequence of litopenaeus vannamei, with mutation type comprising G homozygote, heterozygote of G and three other nucleotides, and homozygoteor heterozygote of three other nucleotides except for G. The invention provides a SNP site for distinguishing ability of litopenaeus vannamei against vibrio harveyi infection, and develops a tetra-primer for amplifying genotype of the SNP site and the detection method for detecting the SNP genotype. The method can simply, rapidly and accurately detects polymorphism forms of the site at low cost, thereby facilitating to rapidly screen individual litopenaeus vannamei and breeding group with high ability against vibrio harveyi, and to maintain antibacterial varieties of litopenaeus vannamei against vibrio harveyi.
Owner:SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
Novel vibrio alginolyticus bacteriophage and composition and application thereof
ActiveCN111718907AEfficient killingHydrophilicAntibacterial agentsBiocideBiotechnologyAquaculture industry
Owner:QINGDAO PHAGEPHARM BIO TECH CO LTD
Artificial compound feed for improving vibrio resistance of penaeus vannamei boone as well as preparation method and application of artificial compound feed
InactiveCN110833128AImprove survival rateHigh activityFood processingClimate change adaptationBiotechnologyAntioxidant
The invention discloses an artificial compound feed for improving vibrio resistance of penaeus vannamei boone as well as a preparation method and an application of the artificial compound feed. The artificial compound feed comprises the following components: fish meal, blood cell powder, squid paste, shrimp shell powder, soybean meal, peanut kernel cakes, cottonseed meal, flour, phospholipid oil,a multi-vitamin multi-mineral premix, monocalcium phosphate, an antioxidant, a mildew preventive, choline chloride and chitosan quaternary ammonium salt. The preparation method comprises the followingsteps: weighing the components, crushing the components except the phospholipid oil, sieving with a 80-100-mesh sieve to obtain a solid crushed material, uniformly mixing the solid crushed material with the phospholipid oil, granulating, cutting, cooling, and sieving to remove powder, thereby obtaining the artificial compound feed capable of improving the vibrio resistance of penaeus vannamei boone. According to the invention, the loss caused by high disease incidence of the penaeus vannamei boone due to vibrio infection can be reduced, and the yield and success rate of the penaeus vannamei boone culture industry are improved.
Owner:ZHUHAI RONGCHUAN FEED
Preparation method and application for human-derived vibrio vulnificus hemolysin (VVH) resistant antibody
ActiveCN105198992AHigh school and VVH capacity of Vibrio vulnificusObvious allergic reactionAntibacterial agentsImmunoglobulins against bacteriaAntigenVibrio pelagius
The invention discloses a preparation method and application of a human-derived VVH resistant antibody. The human-derived VVH resistant antibody is a human-derived antibody and has the capacity of neutralizing VVH. The VVH resistant antibody provided by the invention comprises a light chain variable region and a heavy chain variable region, wherein the amino acid sequence of the heavy chain variable region is 135th-260th amino acid residues from an amino terminal in the sequence 3 in a sequence table; the amino acid sequence of the light chain variable region is 1st-113th amino acid residues from the amino terminal in the sequence 3 in the sequence table. According to the antibody disclosed by the invention, immobilized VVH is used as an antigen, and a constructed human-derived natural high-capacity phage antibody library is used, so that the human-derived VVH resistant antibody is successfully screened, and through ELISA identification, the VVH resistant antibody has good specificity, and has a wide application prospect in treatment of vibrio infection.
Owner:PLA NAVY GENERAL HOSIPTAL
Application of OMP (outer membrane protein) VP1243 to prevention and treatment of Vibrio infection
InactiveCN107982527AImproving immunogenicityGood immune protectionAntibacterial agentsBacteriaAquaculture industryHuman health
The invention discloses an application of OMP (outer membrane protein) VP1243 to prevention and treatment of Vibrio infection. The OMP VP1243 has good immunogenicity and antiserum still has a positivereaction after being diluted 5,000 times or more; the OMP VP1243 further has excellent immune protection, and immunized mice infected with pathogenic Vibrio all survive; animal organisms immunized with the OMP not only can produce antibodies, but also can be protected from diseases caused by further infection with corresponding pathogenic bacteria; subunit vaccines, bacterial live vaccines and the like developed with the OMP VP1243 as the target have great significance in preventing and resisting vibriosis and Vibrio enteritis caused by Vibrio infection, loss of aquaculture industry can be reduced effectively, and food safety and human health are guaranteed.
Owner:ZHEJIANG SCI-TECH UNIV
Expression of vibrio alginolyticus outer membrane protein VA0760 and application thereof as vaccine component
InactiveCN101386642AImproving immunogenicityIncrease resistanceDepsipeptidesImmunological disordersMicrobiologyPseudomonas fluorescens
The invention relates to the expression of a recombined outer membrane protein VA0760 of Vibrio alginolyticus and the action function of a vaccine component. Through cloning, expressing and purifying genes of the recombined outer membrane protein VA0760 of the Vibrio alginolyticus, a purified product can obviously improve the resistance of the fish to pathogenic bacteria such as Vibrio alginolyticus, pseudomonas fluorescens. As a target candidate of a subunit vaccine, the recombined outer membrane protein VA0760 of the Vibrio alginolyticus has great significance on the immunological prevention and treatment of controlling Vibrio infection.
Owner:SUN YAT SEN UNIV
Feed preventing vibrio infection of xenocypris davidi and preparation method thereof
The invention relates to a fish feed, in particular to a feed preventing vibrio infection of xenocypris davidi, and also relates to a preparation method of the mixed feed of xenocypris davidi. The feed preventing vibrio infection of xenocypris davidi comprises: by mass, 20 to 30 parts of fish meal, 8 to 15 parts of soya-bean cake, 5 to 10 parts of rapeseed meal, 6 to 12 parts of rice bran, 3 to 7 parts of hairyvein agrimony, 3 to 8 parts of cassia twig, 2 to 6 parts of perilla, 3 to 7 parts of senecio, 2 to 5 parts of calamus, 2 to 6 parts of gynura bicolor, 1 to 5 parts of prunella vulgaris, 1 to 4 parts of phellodendron, 2 to 6 parts of fish oil, 1 to 4 parts of honey, 1 to 4 parts of olive oil, and 1 to 4 parts of compound vitamin. The invention provides the feed preventing vibrio infection of xenocypris davidi according to the energy metabolism mode and nutritional requirement of the xenocypris davidi, and the feed can improve the antibiotic resistance. Moreover, the xenocypris davidi fed with the feed has low feed coefficient, high specific growth rate, and strong capability of resisting diseases.
Owner:QINGDAO HAIZHIXING BIOLOGICAL SCI & TECH
Vibrio harveyi inactivated vaccine, and preparation method and application thereof
The invention relates to the field of aquatic product vaccinology, and concretely relates to a Vibrio harveyi inactivated vaccine, and a preparation method and an application thereof. The preparationmethod comprises the following steps: inactivating a cultured Vibrio harveyi strain T4 by formaldehyde for 24 h, re-suspending the inactivated strain in PBS until the final concentration is 8.0 * 10<9> cfu / ml, and mixing and emulsifying the obtained mixture with an adjuvant to obtain the Vibrio harveyi inactivated vaccine. The immunoprotection efficiency of the obtained inactivated vaccine againstVibrio harveyi infection can reach 85% or above. The vaccine obtained in the invention has the advantages of simple preparation process, no extraction or purification, no hidden safety hazards, and achieving high-efficiency and long-term immunoprotective effect by one-time immunization.
Owner:INST OF OCEANOLOGY - CHINESE ACAD OF SCI
South America white pair DNA binding antibacterial peptide VPDB40 and application thereof
ActiveCN113087771AEnhanced inhibitory effectAntibacterial agentsPeptide/protein ingredientsDiseaseFeed additive
The invention discloses a penaeus vannamei DNA combined antibacterial peptide VPDB40, wherein the amino acid sequence of the penaeus vannamei DNA combined antibacterial peptide VPDB40 is GITIQCILPGFVVSKLSKLK, and the molecular weight of the antibacterial peptide is 2144.686 Daltons. The antibacterial peptide can effectively inhibit the growth of vibrio parahaemolyticus, and can be used for preparing drugs for preventing or inhibiting vibrio parahaemolyticus infection. The invention lays a foundation for further research on the development of the penaeus vannamei antibacterial peptide as a food preservative and a feed additive for preventing penaeus vannamei diseases.
Owner:JIMEI UNIV
SAA gene related to tridacna immunity and application of gene in preparing tridacna pathological detection reagent
ActiveCN110669769AAvoid elevationHighly innovativeApolipeptidesMicrobiological testing/measurementDiseaseGermplasm
The invention discloses an SAA gene related to tridacna immunity and an application of the gene in preparing a tridacna pathological detection reagent. In the invention, the SAA gene is cloned from tridacna crocea for the first time, and a universal primer TcSAA-F / TcSAA-R is designed for the gene in several common tridacna. Quantitative PCR experiments show that the SAA gene of the tridacna croceais significantly up-regulated after vibrio infection and very similar to that of mammals, and in other pathological conditions, the expression of the gene is also significantly up-regulated. Therefore, the SAA gene can also be used as a gold standard for detecting tridacna health conditions. The SAA gene and the primer TcSAA-F / TcSAA-R provided by the invention can be used to monitor the health conditions of the tridacna, provide a positive and accurate warning signal for the prevention of tridacna diseases, and can effectively prevent the expansion of disasters; and the application of the technology further improves the ability of tridacna breeding germplasm innovation and supports the efficient and sustainable development of industry.
Owner:SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
Preparation method of pathogenic vibrio harveyi DNA (Deoxyribonucleic Acid) template in prawn culture
InactiveCN106636073AEfficient detectionPrevention of vibriosisMicrobiological testing/measurementDNA preparationDiseasePrawn
The invention discloses a preparation method of a pathogenic vibrio harveyi DNA (Deoxyribonucleic Acid) template in prawn culture. The preparation method comprises the following steps: carrying out shaking-bed culture on three test tubes with a liquid culture medium at 28 DEG C for one night; taking out the three test tubes the next day; taking one test tube as a control group and taking two test tubes as experiment groups; opening a clean worktable; firstly, carrying out ultraviolet disinfection for 20min and then putting the test tubes into the clean worktable; selecting one test tube with bacteria, which has a relatively great concentration; sucking 1ml of a bacterium culture solution into a prepared PCR (Polymerase Chain Reaction) tube by utilizing a pipette; adding an equal amount of clean water into the other PCR tube, so as to conveniently symmetrize in a centrifuging process. The preparation method disclosed by the invention is simple and has a simple preparation effect; the template can be used for effectively detecting vibrio infection in a culture water area or tissues in cultured prawns; water quality regulation and control can be carried out in advance, prawn vibrio diseases are prevented early and large-scale outbreak of diseases is prevented and controlled, so that healthy culture of the prawns is effectively improved.
Owner:QINGDAO AGRI UNIV
Expression of vibrio alginolyticus outer membrane protein VA0760 and application thereof as vaccine component
InactiveCN101386643AImproving immunogenicityIncrease resistanceDepsipeptidesImmunological disordersAction functionMicrobiology
The invention relates to the expression of a recombined outer membrane protein Pal (VA1061) of Vibrio alginolyticus and the action function of a vaccine component. Through cloning, expressing and purifying genes of the recombined outer membrane protein Pal (VA1061) of the Vibrio alginolyticus, a purified product can obviously improve the resistance of the fish to pathogenic bacteria such as Vibrio alginolyticus, pseudomonas fluorescens. As a target candidate of a subunit vaccine, the recombined outer membrane protein VA0760 of the Vibrio alginolyticus has great significance on the immunological prevention and treatment of controlling Vibrio infection.
Owner:SUN YAT SEN UNIV
Preparation method of egg yolk antibody for preventing and treating vibrio vulnificus infection
The invention provides an egg yolk antibody for preventing and treating vibrio vulnificus infection. The egg yolk antibody is prepared by the following method: (1) separating vibrio vulnificus from asample of a patient infected with the vibrio vulnificus in natural environment; (2) preparing a vibrio vulnificus inactivation somatic antigen, and carrying out immunization on an egg-laying hen; and(3) collecting immunized eggs, and extracting and purifying the egg yolk antibody from the egg yolks of the eggs. The egg yolk antibody disclosed by the invention can effectively neutralize the vibriovulnificus so as to terminate the vibrio vulnificus infection, and an effective passive immune agent for subsequent prevention and control of the vibrio vulnificus is provided.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
Application of vitamin D3 to aquaculture
ActiveCN111887184AVerification functionReduce fatalityClimate change adaptationAccessory food factorsBiotechnologyDisease
The invention provides an application of vitamin D3 to aquaculture, and belongs to the technical field of aquaculture. According to the vitamin D3 screened based on metabonomics, the fatality rate ofvibrio pathogens to prawns can be reduced, the removal efficiency of intestinal flora of the prawns is improved, and the expression level of antibacterial peptide in digestive tracts of the prawns ispromoted. The application of the vitamin D3 to bacterial disease resistance of the prawns does not cause generation of drug-resistant vibrio, does not cause the problem of environmental pollution, hasno adverse effect on the normal life activity of the prawns, and can improve the vibrio infection resistance of the prawns by adding the vitamin D3 as an immunopotentiator into a prawn feed. The useof antibiotics and pollution to the environment are reduced, and the generation of drug-resistant bacteria in the environment is reduced, so that the vitamin D3 has a good practical application value.
Owner:SHANDONG UNIV
SNP markers for distinguishing resistance to Vibrio harveyi infection of Litopenaeus vannamei and its detection method and application
ActiveCN110791571BQuick checkAccurate detectionMicrobiological testing/measurementDNA/RNA fragmentationBroodstockNucleotide
Owner:SOUTH CHINA SEA INST OF OCEANOLOGY - CHINESE ACAD OF SCI
Expression of vibrio alginolyticus outer membrane protein VA0760 and application thereof as vaccine component
InactiveCN101386642BImproving immunogenicityIncrease resistanceDepsipeptidesImmunological disordersMicrobiologyPseudomonas fluorescens
Owner:SUN YAT SEN UNIV
Preparation method of egg yolk antibody for preventing and treating vibrio vulnificus infection
The invention provides an egg yolk antibody for preventing and treating vibrio vulnificus infection. The egg yolk antibody is prepared by the following method: (1) separating vibrio vulnificus from asample of a patient infected with the vibrio vulnificus in natural environment; (2) preparing a vibrio vulnificus inactivation somatic antigen, and carrying out immunization on an egg-laying hen; and(3) collecting immunized eggs, and extracting and purifying the egg yolk antibody from the egg yolks of the eggs. The egg yolk antibody disclosed by the invention can effectively neutralize the vibriovulnificus so as to terminate the vibrio vulnificus infection, and an effective passive immune agent for subsequent prevention and control of the vibrio vulnificus is provided.
Owner:THE FIRST AFFILIATED HOSPITAL OF SUN YAT SEN UNIV
Feed for preventing and controlling prawn hepatopancreatic necrosis syndrome
The invention discloses a feed for preventing and controlling hepatopancreatic necrosis syndrome of prawns. The feed is characterized in that a Chinese herbal medicine probiotic fermentation additive capable of resisting vibrio parahaemolyticus is sprayed on screened prawn granulated feed or crushed feed, and the additive is prepared by the following steps of: crushing fresh fennel stems and leaves, onion corms and chilies and supplementing a proper amount of nutrients, and carrying out combined fermentation by using bacillus subtilis and clostridium butyricum. The product can effectively reduce vibrio infection of prawns and achieve the purpose of preventing and controlling hepatopancreatic necrosis syndrome of prawns.
Owner:DONGTAI SUTAI FEED
A dna-binding antimicrobial peptide vpdb40 of Penaeus vannamei and its application
ActiveCN113087771BEnhanced inhibitory effectAntibacterial agentsPeptide/protein ingredientsMelicertusAntimicrobial peptides
Owner:JIMEI UNIV
Turbot feed
InactiveCN106173541AMeeting nutritional needsImprove the immunityFood processingClimate change adaptationDiseaseVitamin C
The invention provides a turbot feed, prepared from the following components in parts by weight: 15 to 22 parts of fish meal, 10 to 18 parts of shrimp meal, 20 to 25 parts of bean pulp, 10 to 15 parts of potato flour, 1 to 2 parts of fish oil, 0.2 to 0.5 part of salt, 0.5 to 1 part of vitamin C, 1 to 2 parts of sodium carboxymethylcellulose, 0.2 to 0.3 part of Chinese gall, 0.1 to 0.2 part of herba houttuyniae, 0.3 to 0.5 part of fructus crataegi, 0.1 to 0.2 part of rhizoma coptidis and 1 to 2 parts of dried distilled grains. The turbot feed disclosed by the invention has the advantages that the nutritional requirements of a turbot can be met, and the resistance of the turbot to diseases, such as vibrio infections, is improved, so that a young fish survival rate and adult fish quality are improved, and the economical benefits of aquaculture are improved.
Owner:邵侠
Construction method of model of diarrhea of young rabbits infected by vibrio parahaemolyticus
PendingCN114847233ACorrect reflection of laxative toxicityShort modeling experiment timeAnimal husbandryAgainst vector-borne diseasesDiarrhea symptomsPathogenic bacteria
The invention discloses a construction method of a vibrio parahaemolyticus infected young rabbit diarrhea model, and relates to a food-borne pathogenic bacterium infection model. The construction method comprises the following steps: taking a two-day-old New Zealand young rabbit as a test animal, fasting the obtained young rabbit, performing intragastric administration with vibrio parahaemolyticus, feeding after 8-12 hours, observing the inoculated young rabbit and recording the death condition, dissecting and sampling the dead young rabbit, and recording obvious diarrhea symptoms. The construction method disclosed by the invention is short in experimental time, few in operation times and high in order of magnitude of infected vibrio parahaemolyticus, clinical symptoms and pathological changes of an infected animal model can correctly reflect the diarrheogenic virulence of the vibrio parahaemolyticus, and the model animal is small in size, easy to operate and suitable for being used as a research model of the vibrio parahaemolyticus.
Owner:SHANGHAI OCEAN UNIV
A plant extract composition for anti-vibriosis and its preparation method and application
ActiveCN112516269BImprove the survival rate of breedingImprove survival rateAntibacterial agentsAnimal feeding stuffBiotechnologyMango leaf extract
Owner:INST OF TROPICAL BIOSCI & BIOTECH CHINESE ACADEMY OF TROPICAL AGRI SCI
Lyase from vibrio alginolyticus bacteriophage and application thereof
The invention discloses a co-expression vector of lyase genes holA and lysin of bacteriophage, a recombinant strain of the co-expression vector, a bacteriophage co-expression lyase holA-lysin as well as a preparation method and application of the bacteriophage co-expression lyase holA-lysin. The lyase genes holA and lysin of bacteriophage HH109 are obtained through PCR (Polymerase Chain Reaction) amplification and the like, cloned to an expression system and transferred into a target strain to obtain recombinant bacteria. The recombinant bacterium induces expression of a lyase gene under IPTG, so that efficient splitting of bacteria such as vibrio alginolyticus and escherichia coli is realized, the splitting action has no selectivity, and the broad-spectrum application range is shown. The lyase of the bacteriophage HH109 has potential application value in prevention and treatment of vibrio infection such as vibrio alginolyticus and the like.
Owner:HOHAI UNIV
Preparation method and use method of food-calling vibrio-infection-resistant feed additive
PendingCN112806475AShorten feeding timeReduce vibrio infectionClimate change adaptationAnimal feeding stuffBiotechnologyFeed additive
The invention discloses a preparation method of a food-calling vibrio-infection-resistant feed additive. The preparation method comprises the following steps: crushing fresh foeniculum vulgare stems and leaves, onion bulbs and chilies, squeezing the above materials into juice, supplementing a proper amount of nutrients which are obtained by a combined fermentation of bacillus subtilis and clostridium butyricum. When a proper amount of the feed additive is added into a feed, the feed has very good food-calling and vibrio-resistant effects, can effectively shorten feed intake time of prawns and reduces vibrio infection and a mortality rate of the prawns.
Owner:YANCHENG INST OF TECH
Binding protein of pathogenic vibrio PirB protein and application thereof
ActiveCN114591412AReduce mortalityImprove protectionAntibacterial agentsOrganic active ingredientsBiotechnologyDisease
The invention relates to genetic engineering, in particular to binding protein (LvFABP) of pathogenic vibrio PirB protein and application of the binding protein in prevention and treatment of AHPND (acute hepatopancreatic necrosis disease) of prawns. The invention discloses a binding protein of pathogenic vibrio PirB protein. The base sequence of the binding protein of the pathogenic vibrio PirB protein is as shown in SEQ ID NO: 1. The invention discloses application of double-stranded RNA (dsLvFABP) of a partial gene sequence of binding protein of pathogenic vibrio PirB protein as shown in SEQ ID NO: 1 in inhibition of pathogenic vibrio infection. The base sequence of the double-stranded RNA (dsLvFABP) of the partial gene sequence of the binding protein of the pathogenic vibrio PirB protein is as shown in SEQ ID NO: 2. After the double-stranded RNA is injected, the death rate of prawns infected by pathogenic vibrios can be effectively reduced, and the double-stranded RNA has a remarkable protection effect on prawn culture. The LvFABP gene and the encoding protein thereof can be used for molecular markers for prawn variety breeding, and the double-stranded RNA or the protein antibody can be used for preventing and treating diseases, so that the LvFABP gene has a good application prospect in prawn AHPND prevention and treatment.
Owner:INST OF OCEANOLOGY - CHINESE ACAD OF SCI +1
Rtx toxin production inhibitor and composition for treating symptom of vibrio infection by using same
ActiveUS20200237718A1Inhibit productionAntibacterial agentsOrganic active ingredientsPathogenicityPerylene derivatives
Provided is a method for treating a symptom of vibrio infection by using an RTX toxin production inhibitor comprising N-(4-oxo-4H-thieno[3,4-c]chromen-3-yl)-3-phenylprop-2-ynamide having derivatives thereof which can repress (prevent or treat) a symptom of vibrio infection by inhibiting RTX toxin production, other than directly killing vibrio bacteria, to not allow vibrio bacteria to have pathogenicity, and thereby can be an alternative to antibiotics that aim to kill bacteria themselves and thus fundamentally retain the problem of resistance incurrence.
Owner:SEOUL NAT UNIV R&DB FOUND
Dried yellow croaker flavor peptide Tit5 and application thereof
ActiveCN113861271AEnhanced inhibitory effectAntibacterial agentsPeptide/protein ingredientsBiotechnologyDisease
The invention discloses a dried yellow croaker flavor peptide Tit5 with an amino acid sequence of PVIKWFRR, and the molecular weight of 1101 Daltons. The flavor peptide disclosed by the invention can be used as a novel flavoring agent, has a strong effect of inhibiting the growth of vibrio parahaemolyticus and algicidal vibrio, and can also be used for preparing medicines for preventing or inhibiting vibrio parahaemolyticus and / or algicidal vibrio infection. The invention lays the foundation for the subsequent further studies on the development of the dried yellow croaker flavor peptide as a food preservative and a feed additive for preventing fish diseases.
Owner:JIMEI UNIV
Method for rapidly detecting vibrio mimicus in clinical blood sample
PendingCN113637779AImprove featuresHigh sensitivityMicrobiological testing/measurementDNA/RNA fragmentationA-DNAVirulence factor
The invention discloses a method for rapidly detecting vibrio mimicus in a clinical blood sample. The method comprises the following steps: S1, acquiring a blood sample to be detected, and extracting a DNA template; and S2, performing real-time fluorescence RPA detection by utilizing a combination of a primer and a probe, and judging whether the biological sample is infected with the vibrio mimicus or not according to an amplification result, wherein the primer and the probe are designed by taking a related virulence factor vmhA gene in vibrio mimicus as a target spot. The method has extremely high specificity and sensitivity, and a positive result can be obtained within the shortest 3.32 min by a real-time fluorescence RPA method at a relatively high concentration (3.5*10 < 6 > cfu / mL). The real-time fluorescence RPA method has very good tolerance to inhibitory components in a plasma sample, and can be used for directly amplifying a clinical plasma sample treated by a simple boiling method, so that the whole detection time is shortened. Besides, the real-time RPA method can be combined with portable equipment, and is a very useful method for monitoring mimicry vibrio infection in clinical diagnosis of a mimicry vibrio outbreak site.
Owner:MEI HOSPITAL UNIV OF CHINESE ACAD OF SCI
Preparation method and application of a kind of human source anti-vibrio vulnificus hemolysin protein (vvh) antibody
ActiveCN105198992BHigh school and VVH capacity of Vibrio vulnificusObvious allergic reactionAntibacterial agentsImmunoglobulins against bacteriaAntigenPhage antibodies
The invention discloses a preparation method and application of a human anti-vibrio vulnificus hemolysin protein (VVH) antibody. The human source anti-vibrio vulnificus hemolysin protein (VVH) antibody of the present invention is a human source antibody and has the ability of neutralizing the vibrio vulnificus hemolysin protein VVH. The anti-VVH antibody provided by the present invention includes a light chain variable region and a heavy chain variable region, and the amino acid sequence of the heavy chain variable region is amino acid residues 135-260 from the amino terminal of sequence 3 in the sequence listing , the amino acid sequence of the light chain variable region is amino acid residues 1-113 from the amino terminal of Sequence 3 in the sequence listing. The present invention uses solid-phase Vibrio vulnificus VVH as an antigen and uses the constructed human-derived natural large-capacity phage antibody library to successfully screen human-derived anti-Vibrio vulnificus VVH antibodies. After ELISA identification, the anti-VVH antibody of the present invention has It has good specificity and has broad application prospects in the treatment of Vibrio infection.
Owner:PLA NAVY GENERAL HOSIPTAL
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