The invention relates to the technical field of sheet material, and in particular, relates to a vinyl acetate resin sheet material and a printing and laminating process; the vinyl acetate resin sheet material includes a matte fine-stripe surface layer and a groined-shaped stripe bottom layer, wherein the matte fine-stripe surface layer comprises the following raw materials in parts by weight: 80-120 parts of EVA resin, 80-100 parts of PE resin, 5-15 parts of an elastomer, 1-5 parts of a compatibilizer and 1-3 parts of an antibacterial agent; the groined-shaped stripe bottom layer comprises the following raw materials in parts by weight: 80-120 parts of EVA resin, 83-90 parts of PE resin, 10-15 parts of an elastomer, 1-5 parts of a compatibilizer, and 1-3 parts of a mildewproof agent. The vinyl acetate resin sheet material has the advantages of good antibacterial and mildewproof effects, beautiful patterns, soft texture, comfortable hand feeling, environmental protection, no toxicity, and good transparency and surface glossiness, and also has the advantages of good chemical stability, softness, elasticity, flexibility, slip resistance, abrasion resistance, high temperature resistance, printability, aging prevention, ozone resistance and the like, and has excellent comprehensive performance.