The invention discloses a microalloyed 35Cr45NiNb alloy steel for ethylene cracking furnace tubes, which contains C: 0.40-0.50, Si: 1.20-1.80, Mn: 0.60-1.20, P: 0.001-0.020, S: 0.001 in mass percent ~0.010, Cr: 35~36, Ni: 45~46, Nb: 0.80~1.50, W: 0.005~0.20, Mo: 0.005~0.20, Cu: 0.005~0.30, Al: 0.005~0.20, Ti: 0.05~0.10 , Zr: 0.05-0.10, B: 0.0010-0.0050, As: 0-0.0020, Sn: 0-0.0020, Pb: 0-0.0020, Bi: 0-0.0001, and the balance is Fe. The alloy steel requires columnar grains to account for more than 70% of the wall thickness, and the grain size grade is 5-6. The invention can effectively improve the high-temperature durability performance of the ethylene cracking furnace tube, so that it meets the requirement of a high-temperature durable fracture time greater than 100 hours under the conditions of 1100°C and 17 MPa, thereby achieving the purpose of ensuring long-term safe operation of the ethylene cracking furnace device.