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The invention discloses an anthraquinone hydrogenation non-uniform pore channel partition nickel-based monolithic catalyst and a preparation method thereof. The catalyst consists of a nickel-based monolithic catalyst carrier and a noble metal component, wherein the noble metal component is one or more of palladium, platinum, rhodium and ruthenium; and based on the weight of the catalyst, the catalyst comprises 0.05 to 2 percent, preferably 0.1 to 1 percent, of noble metal component and the balance of the catalyst carrier. The preparation method comprises the following steps: (1) mixing and kneading activated nickel oxide, adhesive and a peptizing agent into plastic paste, putting the paste into a compression die, performing strip extrusion to form a non-uniform pore channel monolithic structure, drying and roasting, and cutting out the required height in the direction vertical to the pore channel to obtain a nickel-based monolithic catalyst carrier containing molybdenum oxide; and (2) dipping one end of the nickel-based monolithic catalyst carrier into a solution containing the noble metal component, performing dipping treatment, and drying and roasting to obtain the catalyst product. The catalyst has the non-uniform pore channel, is applied to hydrogenation process of preparation of hydrogen peroxide by an anthraquinone method, guarantees the reaction activity of the catalyst and improves the reaction selectivity.