The invention discloses an efficient and safe regenerative combustion VOCs purification system. The efficient and safe regenerative combustion VOCs purification system comprises a base, wherein a shell is fixedly installed on the top surface of the base, and a control panel is fixedly installed on the obverse side of the shell. The inlet air flow and the outlet air flow are separated through a flow guide device, the inlet air flow and the outlet air flow cannot be mixed with each other, meanwhile, the flow guide device can transmit the heat of the outlet air flow to the inlet air flow, and thepreheating effect on the inlet air flow is improved. By means of the cooperation of the control panel, a control module, a driving device, a lifting limiting device, a locking device, a rotating device, a conveying device and a pushing device, a sector-shaped catalyst block is automatically replaced in a non-stop mode, and therefore the continuity of the volatile organic chemical treatment process is ensured, manual participation is not required in the sector-shaped catalyst block replacing process, the time and the labor are saved, the automation degree is high, and the practicability of theefficient and safe regenerative combustion VOCs purification system is improved.