The invention relates to an intelligent power supply system with high-voltage photovoltaic charging modules, and the system comprises a plurality of cell panel square arrays, n high-voltage photovoltaic charging modules (1, 2, 3,...,n), a control module, a load management module, a cell management module, a storage battery, and a remote monitoring module. Direct currents of the cell panel square arrays are inputted into a bus, and are processed by the n high-voltage photovoltaic charging modules in parallel connection, and are outputted from the bus. The processed direct currents are respectively inputted into the load management system and the cell management system. The cell management system is connected with the storage battery, and the load management module is connected with a load. Meanwhile, the control module is connected with and controls the n high-voltage photovoltaic charging modules, the load management system and the battery management system, and transmits information to the remote monitoring module. Through the parallel high-voltage input, the efficiency of the system is improved, and the cable capacity is small. Meanwhile, the modules alternately enter a dormant state, thereby prolonging the service life of all modules. The system also achieves the dynamic charging and discharging management, load dynamic connection and battery overcharging and discharging protection through intelligent monitoring.