The invention discloses an efficient non-isothermal compression molding device and method of an ultra-precision glass lens, for solving such problems caused by the existing isothermal hot compression molding device of a precision aspherical glass lens at home and abroad as the molding period is long, the molding efficiency and production efficiency are low, the service life of a mold is short, the utilization rate of the mold is low and the manufacturing cost of a workpiece is high. The non-isothermal compression molding device comprises a workbench, a lower mold holder, an upper mold holder, a pressurizing cloud deck, a vacuum hood, vacuum connecting tubes and the like. The non-isothermal compression molding device disclosed by the invention has the characteristic of parallel operation of heating, molding, annealing and cooling processes, the production efficiency is 2-3 times as high as before, the temperature difference fluctuation of the mold in each cycle can be decreased from more than 500 DEG C to 80 DEG C, the cold-hot fatigue of the mold is effectively reduced, the service life of the mold is significantly prolonged, the utilization ratio of the mold is improved, the manufacturing cost of the workpiece is greatly reduced, the large-scale production of the aspherical glass lens is significantly pushed forward and thus the non-isothermal compression molding device has significant economic value and social benefits and also has wide market prospects.